Zhang YJ, Wen W, Li F, Jian Y, Zhang CM, Yuan MX, Yang Y, Chen FL. Chicken skin mucosa surrounding small colorectal cancer could be an endoscopic predictive marker of submucosal invasion. World J Gastrointest Oncol 2023; 15(6): 1062-1072 [PMID: 37389111 DOI: 10.4251/wjgo.v15.i6.1062]
Corresponding Author of This Article
Meng-Xia Yuan, MD, Doctor, Department of Digestive Diseases, Chengdu Second People’s Hospital, No. 10 Qingyun South Street, Chengdu 610000, Sichuan Province, China. 1062274198@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jun 15, 2023; 15(6): 1062-1072 Published online Jun 15, 2023. doi: 10.4251/wjgo.v15.i6.1062
Chicken skin mucosa surrounding small colorectal cancer could be an endoscopic predictive marker of submucosal invasion
Ying-Jie Zhang, Wu Wen, Fan Li, Yi Jian, Chuan-Ming Zhang, Meng-Xia Yuan, Ye Yang, Feng-Lin Chen
Ying-Jie Zhang, Wu Wen, Fan Li, Yi Jian, Chuan-Ming Zhang, Meng-Xia Yuan, Department of Digestive Diseases, Chengdu Second People’s Hospital, Chengdu 610000, Sichuan Province, China
Ye Yang, Feng-Lin Chen, Graduate School, Chengdu Medical College, Chengdu 610000, Sichuan Province, China
Author contributions: All authors contributed to the study's conception and design; Zhang YJ, Wen W, and Yuan MX performed the material preparation, data collection, and analysis; Zhang YJ wtote the first draft; all authors commented on the previous versions of the manuscript; all authors read and approved the final manuscript.
Institutional review board statement: The study was approved by the Ethics Committee of the Second People's Hospital (approval No: 2021018).
Informed consent statement: The requirement for informed consent was waived because our study does not involve personal privacy and has little risk to patients.
Conflict-of-interest statement: The authors declare no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Meng-Xia Yuan, MD, Doctor, Department of Digestive Diseases, Chengdu Second People’s Hospital, No. 10 Qingyun South Street, Chengdu 610000, Sichuan Province, China. 1062274198@qq.com
Received: January 13, 2023 Peer-review started: January 13, 2023 First decision: February 9, 2023 Revised: February 23, 2023 Accepted: April 23, 2023 Article in press: April 23, 2023 Published online: June 15, 2023 Processing time: 152 Days and 15.5 Hours
ARTICLE HIGHLIGHTS
Research background
Currently, endoscopists frequently decide the treatment of colorectal polyps according to the characteristics of white light endoscopy, and polyps smaller than 2 cm usually do not receive adequate attention, leading to their inappropriate treatment.
Research motivation
Chicken skin mucosa (CSM) surrounding colon polyps is a common endoscopic finding that could be an endoscopic predictive marker of submucosal invasion. Therefore, we should consider the lesions with such characteristics and adopt more appropriate treatment.
Research objectives
To explore potential markers of small colorectal cancer early invasion under white light endoscopy, We found that CSM was more common in early submucosal invasive carcinoma than intramucosal carcinoma. Therefore, a more aggressive treatment should be used rather than cold-snare polypectomy or cold-snare endoscopic mucosal resection.
Research methods
This retrospective cross-sectional study included 198 consecutive patients [233 early colorectal cancers (ECCs)] who underwent endoscopy or surgical procedures. Logistic regression analysis was used to examine the relationship between morphological characteristics, size, CSM prevalence, and invasion depth of ECC under white light endoscopy.
Research results
CSM, a depressed area with clear boundaries, erosion, or ulcer bleeding, and size (≥ 10 mm) were independent risk factors for submucosal invasion in ECC. We should consider the lesions with such characteristics and adopt more appropriate treatment.
Research conclusions
CSM has a clinicopathological value for predicting deep immersion in early colorectal carcinoma in the left colon.
Research perspectives
We will further expand our research to test our conclusions from various geographic, ethnic, and other factors.
