Pan HY, Wang XW, He QX, Lu YD, Zhang WY, Jin JW, Lin B. Efficacy and safety of gastroscopic hemostasis in the treatment of acute gastric hemorrhage: A meta-analysis. World J Gastrointest Oncol 2023; 15(11): 1988-1997 [PMID: 38077648 DOI: 10.4251/wjgo.v15.i11.1988]
Corresponding Author of This Article
Bin Lin, MS, Staff Physician, Department of Emergency Medicine, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, Hangzhou 310005, Zhejiang Province, China. 18268051213@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Nov 15, 2023; 15(11): 1988-1997 Published online Nov 15, 2023. doi: 10.4251/wjgo.v15.i11.1988
Efficacy and safety of gastroscopic hemostasis in the treatment of acute gastric hemorrhage: A meta-analysis
Hai-Yan Pan, Xiao-Wei Wang, Qiong-Xiao He, Yi-Dan Lu, Wan-Yi Zhang, Jian-Wei Jin, Bin Lin
Hai-Yan Pan, Qiong-Xiao He, Wan-Yi Zhang, Bin Lin, Department of Emergency Medicine, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China
Xiao-Wei Wang, Department of Cardiopulmonary Rehabilitation, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China
Yi-Dan Lu, Department of Ultrasound, Zhejiang Cancer Hospital, Hangzhou 310005, Zhejiang Province, China
Jian-Wei Jin, Department of Oncology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China
Author contributions: Lin B and Pan HY contributed to conception and design; Lin B contributed to administrative support; Lin B and Pan HY contributed to provision of study materials or patients; Pan HY, Wang XW, He QX, Lu YD; Zhang WY, Jin JW and Lin B contributed to collection and assembly of data; Lin B and Pan HY contributed to data analysis and interpretation; All authors contributed to manuscript writing, final approval of manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Lin, MS, Staff Physician, Department of Emergency Medicine, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, Hangzhou 310005, Zhejiang Province, China. 18268051213@163.com
Received: August 24, 2023 Peer-review started: August 24, 2023 First decision: September 11, 2023 Revised: September 19, 2023 Accepted: September 27, 2023 Article in press: September 27, 2023 Published online: November 15, 2023 Processing time: 83 Days and 12 Hours
ARTICLE HIGHLIGHTS
Research background
Gastric cancer (GC) is a malignant tumor with a high incidence and mortality rate worldwide for which acute bleeding is a common clinical complication.
Research motivation
Gastroscopic hemostasis is an important method for treating acute bleeding in GC; however, its efficacy and safety remain controversial.
Research objectives
This meta-analysis provides a wealth of evidence emphasizing the effectiveness and safety of endoscopic hemostasis for treating acute gastrointestinal bleeding in patients with GC.
Research methods
Several databases was searched for related to gastroscopic hemostatic treatment for acute GC. The literature was screened according to the inclusion and exclusion criteria, data were extracted, and literature quality was evaluated. The meta-analysis was performed using RevMan software (version 5.3), while Begg’s test for publication bias was performed using Stata 13.0 software.
Research results
Compared with the control group, the hemostatic rate of gastroscopic hemostasis was increased [relative risk (RR) = 1.24; 95% confidence interval (CI) = 1.08-1.43; P = 0.003]; the rate of rebleeding (RR = 0.27; 95%CI: 0.09 to 0.80; P = 0.02), rate of surgery transfer (RR = 0.16; 95%CI: 0.06 to 0.43; P = 0.0003), serum C-reactive protein level [mean difference (MD) = -5.16; 95%CI: -6.11 to 4.21; P < 0.00001], interleukin-6 level (MD = -6.37; 95%CI: -10.33 to -2.42; P = 0.002), and tumor necrosis factor-α level (MD=-2.29; 95%CI: -4.06 to -0.52; P = 0.01) were decreased; and the quality of life improvement rate was increased (RR = 1.95; 95%CI: 1.41 to 2.71; P < 0.0001).
Research conclusions
The efficacy and safety of endoscopic hemostasis were higher than those of the control group.
Research perspectives
Endoscopic hemostasis is an effective treatment for acute GC hemorrhage.
