Published online Jan 15, 2023. doi: 10.4251/wjgo.v15.i1.90
Peer-review started: September 30, 2022
First decision: October 21, 2022
Revised: October 28, 2022
Accepted: December 21, 2022
Article in press: December 21, 2022
Published online: January 15, 2023
Processing time: 101 Days and 23 Hours
Heat clearing and detoxification drugs are commonly used in traditional Chinese medicine to treat colorectal cancer, but the mechanism is not clear.
We hope that our study can provide a new perspective to the anti-cancer mechanism of heat-clearing and detoxifying therapy, and bring new drugs for the treatment of colorectal cancer (CRC).
This study aims to systematically explore the anticancer mechanism of heat clearing and detoxifying drug JC724.
We identified JC724 active components and targets by database, and then determined CRC related targets through the database and transcriptome analysis. We used network pharmacology to analyze the active herbal ingredients, core targets and main mechanisms of JC724 in the treatment of CRC.
We found that the five ingredients with the most targets were quercetin, β Beta sitosterol, wogonin, kaempferol and baicalein, which were the core ingredients. The core JC724-CRC targets were CYP1A1, HMOX1, CXCL8, NQO1 and FOSL1. JC724 mainly acts on CRC through Nrf2 signaling pathway, oxidative stress and IL-17 signaling pathway.
This study systematically analyzed the mechanism of heat clearing and detoxification drug JC724 in the treatment of CRC, providing direction for further experiments.
This study provides a new perspective on the anti-cancer mechanism of heat clearing and detoxifying drug drugs. Combined with the theory of traditional Chinese medicine, this study can provide direction for research and clinical treatment in the future.