Song WP, Wang SY, Zhou SC, Wu DS, Xie JY, Liu TT, Wu XZ, Che GW. Prognostic and clinicopathological value of Twist expression in esophageal cancer: A meta-analysis. World J Gastrointest Oncol 2022; 14(9): 1874-1886 [PMID: 36187399 DOI: 10.4251/wjgo.v14.i9.1874]
Corresponding Author of This Article
Guo-Wei Che, MD, PhD, Chief Doctor, Surgeon, Lung Cancer Center, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu 610041, Sichuan Province, China. cheguoweixw@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Wen-Peng Song, Guo-Wei Che, Lung Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Su-Yan Wang, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Si-Cheng Zhou, Dong-Sheng Wu, Xiu-Zhu Wu, West China School of Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China
Jia-Yu Xie, Laboratory Experiments in Microbiology, Shuang Liu Center for Disease Control and Prevention, Chengdu 610041, Sichuan Province, China
Tong-Tong Liu, West China School of Public Health & West China Fourth Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Song WP, Wang SY, Zhou SC and Che GW designed the research; Song WP, Zhou SC, Wu DS, Wu XZ and Xie JY conducted the literature search; Song WP and Wang SY collected and retrieved the data; Song WP, Wang SY, Wu DS, Wu XZ, Liu TT and Xie JY analyzed the data; Song WP wrote and revised the manuscript; Liu TT and Che GW contributed to editing; All authors approved the final version.
Conflict-of-interest statement: No conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Wei Che, MD, PhD, Chief Doctor, Surgeon, Lung Cancer Center, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu 610041, Sichuan Province, China. cheguoweixw@126.com
Received: March 16, 2022 Peer-review started: March 16, 2022 First decision: June 12, 2022 Revised: June 30, 2022 Accepted: July 31, 2022 Article in press: July 31, 2022 Published online: September 15, 2022 Processing time: 176 Days and 21.1 Hours
ARTICLE HIGHLIGHTS
Research background
Twist can induce epithelial–mesenchymal transition (EMT) and cancer metastasis. However, the prognostic value of Twist expression in patients with esophageal cancer remains controversial.
Research motivation
To clarify whether Twist could be a promising biomarker for predicting prognosis in esophageal cancer.
Research objectives
To investigate the prognostic and clinicopathological value of Twist expression in esophageal cancer.
Research methods
Published literature in several databases was searched for eligible articles. Participants with esophageal cancer whose tumor tissues underwent immunohistochemistry to detect the expression of Twist were considered when they met the inclusion criteria. The hazard ratio (HR) and relative ratio (RR) with their 95%CI were pooled. Heterogeneity was estimated by I2 statistics.
Research results
The pooled HR for overall survival was 1.88 (95%CI: 1.32-2.69, I2 = 68.6%), and the pooled HR for disease-free survival/relapse-free survival/progression-free survival was 1.84 (95%CI: 1.12-3.02, I2 = 67.1%). In addition, overexpression of Twist was correlated with T stage (T3 + T4 vs T1 + T2, RR = 1.38, 95%CI: 1.14-1.67), lymph node metastasis (yes vs no, RR = 1.34, 95%CI: 1.11-1.60), distant metastasis (yes vs no, RR = 1.18, 95%CI: 1.02-1.35), tumor, node and metastasis (TNM) stage (III + IV vs I + II, RR = 1.35, 95%CI: 1.14-1.60), and clinical stage (III + IV vs I + II, RR = 1.58, 95%CI: 1.34-1.87).
Research conclusions
Twist overexpression indicates poor esophageal cancer prognosis. Moreover, Twist overexpression is correlated with T stage, lymph node metastasis, distant metastasis, TNM stage, and clinical stage, which indicates that Twist might accelerate esophageal cancer progression and metastasis.
Research perspectives
Our meta-analysis suggests that Twist might be a valuable prognostic biomarker in esophageal cancer.
