Hao MZ, Hu YB, Chen QZ, Chen ZX, Lin HL. Efficacy and safety of computed tomography-guided microwave ablation with fine needle-assisted puncture positioning technique for hepatocellular carcinoma. World J Gastrointest Oncol 2022; 14(9): 1727-1738 [PMID: 36187402 DOI: 10.4251/wjgo.v14.i9.1727]
Corresponding Author of This Article
Ming-Zhi Hao, MM, Professor, Department of Tumor Interventional Radiology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, No. 420 Fuma Road, Fuzhou 350014, Fujian Province, China. haomz@fjzlhospital.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Sep 15, 2022; 14(9): 1727-1738 Published online Sep 15, 2022. doi: 10.4251/wjgo.v14.i9.1727
Efficacy and safety of computed tomography-guided microwave ablation with fine needle-assisted puncture positioning technique for hepatocellular carcinoma
Ming-Zhi Hao, Yu-Bin Hu, Qi-Zhong Chen, Zhang-Xian Chen, Hai-Lan Lin
Ming-Zhi Hao, Yu-Bin Hu, Qi-Zhong Chen, Zhang-Xian Chen, Hai-Lan Lin, Department of Tumor Interventional Radiology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou 350014, Fujian Province, China
Ming-Zhi Hao, Department of Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fujian Cancer Hospital, Fuzhou 350014, Fujian Province, China
Author contributions: Hao MZ, Chen QZ, Hu YB, and Lin HL participated in the microwave ablation operation; Hao MZ participated in the data analysis and interpretation, manuscript writing, and final approval of the manuscript; Chen ZX contributed to the data collection and assembly; Lin HL participated in the conception and design.
Supported bythe Fujian Key Laboratory of Translational Cancer Medicine and Fujian Provincial Clinical Research Center for Cancer Radiotherapy and Immunotherapy, China, No. 2020Y2012.
Institutional review board statement: The protocol was approved by the ethics committee of Fujian Provincial Tumor Hospital (approval No. 2018-022-02).
Informed consent statement: Written informed consent was obtained from each patient before study initiation.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Zhi Hao, MM, Professor, Department of Tumor Interventional Radiology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, No. 420 Fuma Road, Fuzhou 350014, Fujian Province, China. haomz@fjzlhospital.com
Received: March 14, 2022 Peer-review started: March 14, 2022 First decision: April 11, 2022 Revised: April 18, 2022 Accepted: July 31, 2022 Article in press: July 31, 2022 Published online: September 15, 2022 Processing time: 178 Days and 22.7 Hours
ARTICLE HIGHLIGHTS
Research background
Due to the influence of the gas, the subphrenic area is one of the most difficult places for ultrasound guidance. A computed tomography (CT) scan can compensate for this shortcoming. CT-guided ablation is a commonly used ablation image-guided method in our department.
Research motivation
CT-guided puncture does not allow for real-time positioning and the microwave electrode needle will produce artifacts in CT scanning, which is different from our previous application of radiofrequency ablation.
Research objectives
To compare fine needle-assisted puncture (FNP) positioning technique and conventional puncture technique for the safety and efficacy of CT-guided microwave ablation (MWA) in treating hepatocellular carcinoma (HCC).
Research methods
The efficacy and safety were compared between the patients received CT-guided MWA under FNP technique and patients received MWA under conventional puncture technique.
Research results
The 1-, 2-, and 3-year cumulative incidences of local tumor progression (LTP) in the FNP group were significantly lower than those in the conventional puncture (CP) technique (CP group). The 1-, 2-, and 3-year RFS rates in the FNP group were significantly higher than those in the CP group. The FNP technique independently predicted LTP and recurrence-free survival (RFS). The minor complications in the FNP group were lower those in the CP group.
Research conclusions
The FNP technique used in CT-guided MWA may improve outcomes in terms of LTP, RFS, and procedure-related complications for HCC.
Research perspectives
Prospective multicenter randomized controlled studies must be conducted in the future to obtain further insights.
