Wang NJ, Chai NL, Tang XW, Li LS, Zhang WG, Linghu EQ. Clinical efficacy and prognostic risk factors of endoscopic radiofrequency ablation for gastric low-grade intraepithelial neoplasia. World J Gastrointest Oncol 2022; 14(3): 724-733 [PMID: 35321273 DOI: 10.4251/wjgo.v14.i3.724]
Corresponding Author of This Article
En-Qiang Linghu, MD, PhD, Chief Doctor, Chief Physician, Director, Professor, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. linghuenqiang@vip.sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nan-Jun Wang, Ning-Li Chai, Xiao-Wei Tang, Long-Song Li, Wen-Gang Zhang, En-Qiang Linghu, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Wang NJ and Chai NL are co-first authors and contributed equally to this work; Wang NJ and Chai NL designed and performed the research and wrote the paper; Tang XW designed the research and supervised the report; Li LS designed the research and contributed to the analysis; Zhang WG supervised the report; Linghu EQ designed the research and provided clinical advice.
Supported byNational Key R&D Program of China, No. 2016YFC1303601.
Institutional review board statement: The Medical Ethics Committee of the PLA General Hospital agreed to exempt this study from medical ethics review.
Informed consent statement: All patients have signed informed consent forms.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: En-Qiang Linghu, MD, PhD, Chief Doctor, Chief Physician, Director, Professor, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. linghuenqiang@vip.sina.com
Received: November 1, 2021 Peer-review started: November 1, 2021 First decision: December 2, 2021 Revised: December 15, 2021 Accepted: February 27, 2022 Article in press: February 27, 2022 Published online: March 15, 2022 Processing time: 129 Days and 0.4 Hours
ARTICLE HIGHLIGHTS
Research background
The efficacy and prognostic risk factors of radiofrequency ablation (RFA) for gastric low-grade intraepithelial neoplasia (LGIN) have not been well analyzed.
Research motivation
We look forward to promoting the use of RFA ablation for gastric LGIN in the future.
Research objectives
To explore the efficacy and prognostic risk factors of RFA for gastric LGIN.
Research methods
The large sample clinical data of RFA for gastric LGIN were reviewed in this retrospective study. Data on operative parameters, complications, and follow-up outcomes including curative rates were recorded and analyzed.
Research results
The near- and long-term efficiency of RFA is satisfactory. Multivariate analyses revealed that Helicobacter pylori (H. pylori) infection and disease duration > 1 year had a significant effect on the curative rate. None of patients had bleeding, perforation, infection, or other serious complications after RFA, and the main discomfort was postoperative abdominal pain.
Research conclusions
RFA is a safe and effective treatment strategy for gastric LGIN, which is worthy of clinical application and promotion. H. pylori infection and disease course > 1 year may be the main risk factors leading to relapse of LGIN after RFA.
Research perspectives
We look forward to conducting a multicenter prospective controlled study in the future to further confirm the efficacy of RFA in the treatment of gastric LGIN.
