Kang WZ, Zhong YX, Ma FH, Xue LY, Xiong JP, Ma S, Li Y, Xie YB, Quan X, Tian YT. Survival outcomes and prognostic indicators for gastric cancer patients with positive peritoneal wash cytology but no peritoneal metastasis after radical gastrectomy. World J Gastrointest Oncol 2021; 13(1): 24-36 [PMID: 33510847 DOI: 10.4251/wjgo.v13.i1.24]
Corresponding Author of This Article
Yan-Tao Tian, MD, Professor, Surgeon, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. tianyantao@cicams.ac.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jan 15, 2021; 13(1): 24-36 Published online Jan 15, 2021. doi: 10.4251/wjgo.v13.i1.24
Survival outcomes and prognostic indicators for gastric cancer patients with positive peritoneal wash cytology but no peritoneal metastasis after radical gastrectomy
Wen-Zhe Kang, Yu-Xin Zhong, Fu-Hai Ma, Jian-Ping Xiong, Shuai Ma, Yang Li, Yi-Bin Xie, Xu Quan, Yan-Tao Tian, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Li-Yan Xue, Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing 100021, China
Author contributions: Tian YT and Xue LY designed the research; Kang WZ, Zhong YX, Ma FH, Xiong JP, and Ma S analyzed the data and wrote the paper; Li Y, Xie YB, and Xu Q collected the patient’s clinical data; Kang WZ and Zhong YX contributed equally to this work.
Supported byNational Natural Science Foundation of China, No. 81772642
Institutional review board statement: This study was approved by the Institutional Review Board of the National Cancer Center Hospital.
Informed consent statement: The need for informed consent was waived due to the retrospective nature of the study, and the data were anonymously analyzed.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to report.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at tyt67@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Tao Tian, MD, Professor, Surgeon, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. tianyantao@cicams.ac.cn
Received: September 8, 2020 Peer-review started: September 8, 2020 First decision: October 21, 2020 Revised: November 3, 2020 Accepted: November 29, 2020 Article in press: November 29, 2020 Published online: January 15, 2021 Processing time: 121 Days and 0.9 Hours
ARTICLE HIGHLIGHTS
Research background
Positive peritoneal wash cytology with no peritoneal metastasis (CY1P0) is a special distant metastasis of gastric cancer, and currently there are no extensive treatment guidelines for patients with CY1P0 gastric cancer.
Research motivation
To assess survival after radical gastrectomy for CY1P0 gastric cancer and to identify factors associated with long-term prognosis.
Research objectives
To evaluate the effect of radical gastrectomy on survival in patients with CY1P0 gastric cancer, and to identify prognostic risk factors.
Research methods
Our study included 48 patients with primary CY1P0 gastric cancer who had radical gastrectomies. Overall survival (OS) statistics were available for 48 patients. Follow-up continued through March 2020. Univariate and multivariate analyses were performed using a Cox proportional hazards model to identify prognostic factors.
Research results
For the 48 CY1P0 patients, median OS was 22.0 mo, while the OS of patients who received chemotherapy alone was 9.9-12.6 mo. Pathological N factor (P = 0.001) and vascular invasion (P = 0.031) were significant independent risk factors for OS.
Research conclusions
This study illustrated the efficacy of radical gastrectomy for CY1P0 gastric cancer patients. More effective treatment should be established for patients who are diagnosed with pN3b disease and vascular invasion.
Research perspectives
To formulate the standard treatment plan for CY1P0 gastric cancer.
