Systematic Reviews
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2016; 8(7): 573-582
Published online Jul 15, 2016. doi: 10.4251/wjgo.v8.i7.573
Systematic review of laparoscopic vs open surgery for colorectal cancer in elderly patients
Shoichi Fujii, Mitsuo Tsukamoto, Yoshihisa Fukushima, Ryu Shimada, Koichi Okamoto, Takeshi Tsuchiya, Keijiro Nozawa, Keiji Matsuda, Yojiro Hashiguchi
Shoichi Fujii, Mitsuo Tsukamoto, Yoshihisa Fukushima, Ryu Shimada, Koichi Okamoto, Takeshi Tsuchiya, Keijiro Nozawa, Keiji Matsuda, Yojiro Hashiguchi, Department of Surgery, Teikyo University School of Medicine, Tokyo 173-8605, Japan
Author contributions: Fujii S wrote the paper; Tsukamoto M, Fukushima Y, Shimada R, Okamoto K, Tsuchiya T, Nozawa K and Matsuda K performed the collected the data; Hashiguchi Y generalized and guided the paper production.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shoichi Fujii, MD, PhD, Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan. sfujii631011@med.teikyo-u.ac.jp
Telephone: +81-3-39641231 Fax: +81-3-53756097
Received: March 4, 2016
Peer-review started: March 7, 2016
First decision: April 15, 2016
Revised: April 15, 2016
Accepted: May 17, 2016
Article in press: May 27, 2016
Published online: July 15, 2016
Processing time: 125 Days and 21.9 Hours
Abstract

AIM: To verify the safety and validity of laparoscopic surgery for the treatment of colorectal cancer in elderly patients.

METHODS: A meta-analysis was performed of a systematic search of studies on an electronic database. Studies that compared laparoscopic colectomy (LAC) in elderly colorectal cancer patients with open colectomy (OC) were retrieved, and their short and long-term outcomes compared. Elderly people were defined as 65 years old or more. Inclusion criteria were set at: Resection of colorectal cancer, comparison between laparoscopic and OC and no significant difference in backgrounds between groups.

RESULTS: Fifteen studies were identified for analysis. LAC was performed on 1436 patients, and OC performed on 1810 patients. In analyses of short-term outcomes, operation time for LAC was longer than for OC (mean difference = 34.4162, 95%CI: 17.8473-50.9851, P < 0.0001). The following clinical parameters were lower in LAC than in OC: Amount of estimated blood loss (mean difference = -93.3738, 95%CI: -132.3437 to -54.4039, P < 0.0001), overall morbidity (OR = 0.5427, 95%CI: 0.4425-0.6655, P < 0.0001), incisional surgical site infection (OR = 0.6262, 95%CI: 0.4310-0.9097, P = 0.0140), bowel obstruction and ileus (OR = 0.6248, 95%CI: 0.4519-0.8638, P = 0.0044) and cardiovascular complications (OR = 0.4767, 95%CI: 0.2805-0.8101, P = 0.0062). In analyses of long-term outcomes (median follow-up period: 36.4 mo in LAC, 34.3 mo in OC), there was no significant difference in overall survival (mean difference = 0.8321, 95%CI: 0.5331-1.2990, P = 0.4187) and disease specific survival (mean difference = 1.0254, 95%CI: 0.6707-1.5675, P = 0.9209). There was also no significant difference in the number of dissected lymph nodes (mean difference = -0.1360, 95%CI: -4.0553-3.7833, P = 0.9458).

CONCLUSION: LAC in elderly colorectal cancer patients had benefits in short-term outcomes compared with OC except operation time. The long-term outcomes and oncological clearance of LAC were similar to that of OC. These results support the assertion that LAC is an effective procedure for elderly patients with colorectal cancer.

Keywords: Laparoscopic surgery; Systematic review; Meta-analysis; Colorectal cancer; Elderly patient

Core tip: Safety and effectiveness of laparoscopic surgery (LAC) in elderly has been unknown. A meta-analysis was performed of a systematic search of studies on an electronic database. Studies that compared LAC in elderly colorectal cancer patients with open colectomy (OC) were retrieved, and their short and long-term outcomes compared. Fifteen studies which had 1436 LAC and 1810 OC were identified. In short-term outcomes, blood loss, morbidity, incisional surgical site infection, bowel obstruction and cardiovascular complications were superior in LAC except operation time. There was no significant difference in long-term outcomes. LAC is an effective procedure for elderly with colorectal cancer.