Published online Apr 15, 2016. doi: 10.4251/wjgo.v8.i4.330
Peer-review started: May 6, 2015
First decision: September 8, 2015
Revised: January 13, 2016
Accepted: January 28, 2016
Article in press: January 31, 2016
Published online: April 15, 2016
MicroRNAs (miRNAs) are key regulators involved in various tumors. They regulate cell cycle, apoptosis and cancer stemness, metastasis and chemoresistance by controlling their target gene expressions. Here, we mainly discuss the potential uses of miRNAs in colorectal cancer (CRC) diagnosis. We also shed light on the important corresponding miRNA targets and on the major regulators of miRNAs. Furthermore, we discuss miRNA activity in assessing the prognosis and recurrence of CRC as well as in modulating responsiveness to chemotherapy. Based on the various pro-oncogenic/anti-oncogenic roles of miRNAs, the advantages of a therapeutic strategy based on the delivery of miRNA mimics are also mentioned. Together, miRNA seems to be an excellent tool for effectively monitoring and targeting CRC.
Core tip: MicroRNAs (miRNAs) regulate oncogenesis, metastasis and chemotherapy by controlling corresponding target gene expressions. Here, we shed light on the diagnostic and prognostic value of some miRNAs in colorectal cancer and potential miRNA-based therapy was also discussed. We hope that this review will offer useful information for researchers who work in a related field.