Yi R, Li Y, Wang FL, Miao G, Qi RM, Zhao YY. MicroRNAs as diagnostic and prognostic biomarkers in colorectal cancer. World J Gastrointest Oncol 2016; 8(4): 330-340 [PMID: 27096028 DOI: 10.4251/wjgo.v8.i4.330]
Corresponding Author of This Article
Yan-Yang Zhao, MD, PhD, the Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, Ministry of Health, No.1, DaHua Road, Dong Dan, Beijing 100730, China. yanyangzhaobj@gmail.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Apr 15, 2016; 8(4): 330-340 Published online Apr 15, 2016. doi: 10.4251/wjgo.v8.i4.330
MicroRNAs as diagnostic and prognostic biomarkers in colorectal cancer
Rui Yi, Yao Li, Fei-Liang Wang, Gang Miao, Ruo-Mei Qi, Yan-Yang Zhao
Rui Yi, Ruo-Mei Qi, Yan-Yang Zhao, the Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China
Yao Li, Fei-Liang Wang, Gang Miao, Department of Surgery, Beijing Hospital, Ministry of Health, Beijing 100730, China
Author contributions: Yi R, Li Y, Wang FL and Zhao YY wrote the paper; Miao G, Qi RM and Zhao YY fully discussed the paper.
Supported by Municipal Natural Science Foundation of Beijing of China, No. 5102039; and National Natural Science Foundation of China, Nos. 81101859, 81270379, 81070231.
Conflict-of-interest statement: The manuscript was approved by all the authors. The authors declare no competing financial interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yan-Yang Zhao, MD, PhD, the Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, Ministry of Health, No.1, DaHua Road, Dong Dan, Beijing 100730, China. yanyangzhaobj@gmail.com
Telephone: +86-10-58115045 Fax: +86-10-65132969
Received: April 28, 2015 Peer-review started: May 6, 2015 First decision: September 8, 2015 Revised: January 13, 2016 Accepted: January 28, 2016 Article in press: January 31, 2016 Published online: April 15, 2016 Processing time: 337 Days and 3.9 Hours
Abstract
MicroRNAs (miRNAs) are key regulators involved in various tumors. They regulate cell cycle, apoptosis and cancer stemness, metastasis and chemoresistance by controlling their target gene expressions. Here, we mainly discuss the potential uses of miRNAs in colorectal cancer (CRC) diagnosis. We also shed light on the important corresponding miRNA targets and on the major regulators of miRNAs. Furthermore, we discuss miRNA activity in assessing the prognosis and recurrence of CRC as well as in modulating responsiveness to chemotherapy. Based on the various pro-oncogenic/anti-oncogenic roles of miRNAs, the advantages of a therapeutic strategy based on the delivery of miRNA mimics are also mentioned. Together, miRNA seems to be an excellent tool for effectively monitoring and targeting CRC.
Core tip: MicroRNAs (miRNAs) regulate oncogenesis, metastasis and chemotherapy by controlling corresponding target gene expressions. Here, we shed light on the diagnostic and prognostic value of some miRNAs in colorectal cancer and potential miRNA-based therapy was also discussed. We hope that this review will offer useful information for researchers who work in a related field.
