Zhong JL, Huang CZ. Ubiquitin proteasome system research in gastrointestinal cancer. World J Gastrointest Oncol 2016; 8(2): 198-206 [PMID: 26909134 DOI: 10.4251/wjgo.v8.i2.198]
Corresponding Author of This Article
Chang-Zhi Huang, Professor, Department of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. huangpumc@163.com
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Feb 15, 2016; 8(2): 198-206 Published online Feb 15, 2016. doi: 10.4251/wjgo.v8.i2.198
Ubiquitin proteasome system research in gastrointestinal cancer
Jia-Ling Zhong, Chang-Zhi Huang
Jia-Ling Zhong, Clinical Laboratory Department, Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China
Chang-Zhi Huang, Department of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Zhong JL and Huang CZ wrote and revised the manuscript.
Supported by The National Natural Science Foundation of China, No. 81472208; the Open Projects of State Key Laboratory of Molecular Oncology, No. SKL-KF-2015-12; and the Doctoral Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital (2013), No. 30305030579.
Conflict-of-interest statement: The authors declare no conflict of interest related to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chang-Zhi Huang, Professor, Department of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. huangpumc@163.com
Telephone: +86-10-87787605 Fax: +86-10-87788426
Received: April 28, 2015 Peer-review started: May 4, 2015 First decision: September 25, 2015 Revised: October 25, 2015 Accepted: November 13, 2015 Article in press: November 17, 2015 Published online: February 15, 2016 Processing time: 280 Days and 18.2 Hours
Abstract
The ubiquitin proteasome system (UPS) is important for the degradation of proteins in eukaryotic cells. It is involved in nearly every cellular process and plays an important role in maintaining body homeostasis. An increasing body of evidence has linked alterations in the UPS to gastrointestinal malignancies, including esophageal, gastric and colorectal cancers. Here, we summarize the current literature detailing the involvement of the UPS in gastrointestinal cancer, highlighting its role in tumor occurrence and development, providing information for therapeutic targets research and anti-gastrointestinal tumor drug design.
Core tip: The ubiquitin proteasome system (UPS) is involved in almost every cellular process, playing an important role in maintaining body homeostasis. Increasing evidence indicates that alterations in the UPS are correlated with gastrointestinal malignancies. Here, we review current information describing UPS members involved in gastrointestinal cancer, providing a resource for further study and clinical application.
