Outcome of curative resection for perihilar cholangiocarcinoma in Northeast Thailand
Attapol Titapun, Ake Pugkhem, Vor Luvira, Tharatip Srisuk, Ongart Somintara, O-tur Saeseow, Anan Sripanuskul, Anongporn Nimboriboonporn, Bandit Thinkhamrop, Narong Khuntikeo
Attapol Titapun, Ake Pugkhem, Vor Luvira, Tharatip Srisuk, Ongart Somintara, O-tur Saeseow, Anan Sripanuskul, Anongporn Nimboriboonporn, Narong Khuntikeo, Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
Bandit Thinkhamrop, Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen 40002, Thailand
Attapol Titapun, Ake Pugkhem, Bandit Thinkhamrop, Narong Khuntikeo, CASCAP Program, Khon Kaen University, Khon Kaen 40002, Thailand
Attapol Titapun, Ake Pugkhem, Narong Khuntikeo, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
Author contributions: Titapun A and Pugkhem A are co-first authors and contributed equally to this work; Titapun A, Pugkhem A and Khuntikeo N designed the study; Titapun A, Pugkhem A, Luvira V, Srisuk T, Somintara O, Saeseow O, Sripanuskul A, Nimboriboonporn A and Khuntikeo N performed the research and acquired the data; Titapun A, Pugkhem A Thinkhamrop B and Khuntikeo N analyzed the data; Titapun A, Pugkhem A and Khuntikeo N drafted the manuscript; Titapun A, Pugkhem A and Khuntikeo N designed the study; Titapun A, Pugkhem A, Luvira V, Srisuk T, Somintara O, Saeseow O, Sripanuskul A, Nimboriboonporn A, Thinkhamrop B and Khuntikeo N contributed significantly to the revision of the manuscript.
Supported by Khon Kaen University through CASCAP and the National Research Council of Thailand through the Medical Research Network of the Consortium of Thai Medical Schools.
Institutional review board statement: The entire study was carried out in strict accordance with protocols approved by Institutional Ethics Committee, Khon Kaen University (Ethics Permit Number: 571283).
Clinical trial registration statement: There are no randomized trials to prove the benefit of chemotherapy in an adjuvant setting. This study was not designed to prove the benefit of chemotherapy but there is one retrospective study from our institute from the years 2009-2011 that may imply benefit of adjuvant chemotherapy.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at nkhuntikeo@gmail.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Narong Khuntikeo, MD, Department of Surgery, Faculty of Medicine, Khon Kaen University, Mittraphap 18 Alley, Nai Mueang, Mueang Khon Kaen District, Khon Kaen 40002, Thailand.
nkhuntikeo@gmail.com
Telephone: +66-43-348393 Fax: +66-43-348393
Received: August 3, 2015
Peer-review started: August 4, 2015
First decision: September 14, 2015
Revised: September 27, 2015
Accepted: October 20, 2015
Article in press: October 27, 2015
Published online: December 15, 2015
Processing time: 133 Days and 5.3 Hours
