Santos MD, Bouhier K, Dao MT. Paraneoplastic leukemoid reaction in pancreatic cancer: A case report. World J Gastrointest Oncol 2015; 7(10): 259-262 [PMID: 26483880 DOI: 10.4251/wjgo.v7.i10.259]
Corresponding Author of This Article
Manh-Thong Dao, Professor, Doctor of Hepato-Gastroenterology, Department of Gastroenterology, CHU Caen, Avenue Côte de Nacre, 14000 Caen, France. dao-t@chu-caen.fr
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Oct 15, 2015; 7(10): 259-262 Published online Oct 15, 2015. doi: 10.4251/wjgo.v7.i10.259
Paraneoplastic leukemoid reaction in pancreatic cancer: A case report
Mélanie Dos Santos, Karine Bouhier, Manh-Thong Dao
Mélanie Dos Santos, Karine Bouhier, Manh-Thong Dao, Department of Gastroenterology, CHU de Caen, 14000 Caen, France
Author contributions: Dos Santos M performed the research and wrote the paper; all authors contributed to revision of this manuscript.
Supported by The University Caen Basse Normandie, 14000 Caen, France.
Institutional review board statement: This case report was exempt from the Institutional Review Board: Comité de protection des personnes Nord Ouest III at CHU Caen.
Informed consent statement: The patient involved in this study died before the manuscript was written. However data are anonymized not to cause harm to the patient or their families, and risk of identification is low.
Conflict-of-interest statement: No conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Manh-Thong Dao, Professor, Doctor of Hepato-Gastroenterology, Department of Gastroenterology, CHU Caen, Avenue Côte de Nacre, 14000 Caen, France. dao-t@chu-caen.fr
Telephone: +33-23-1064544 Fax: +33-23-1064545
Received: April 3, 2015 Peer-review started: April 3, 2015 First decision: July 10, 2015 Revised: July 20, 2015 Accepted: August 4, 2015 Article in press: August 7, 2015 Published online: October 15, 2015 Processing time: 199 Days and 6.8 Hours
Abstract
Paraneoplastic leukemoid reaction is a rare syndrome defined by a leukocyte count exceeding 50 Giga/Liter (G/L), mostly described with progressive lung or renal carcinoma. We report a case of a 68-year-old man with recurrent pancreatic carcinoma presenting a leukemoid reaction with a white blood cell count of 63.87 G/L without identified infectious, iatrogenic or hematologic causes. His overall condition quickly degraded and he died three weeks after the discovery of the leukemoid reaction. This is the first case in French literature of leukemoid reaction in a patient with pancreatic carcinoma with poor prognostic value.
Core tip: Paraneoplastic leukemoid reaction is a rare syndrome which seems to be associated with aggressive tumors, rapid clinical deterioration, and short survival. We report a rare presentation of pancreatic cancer with leukemoid reaction in a 68-year-old man who died three weeks after its discovery. This paper may contribute to clinical practice when encountering such a patient because of its poor prognostic value.
