Cipe G, Idiz UO, Firat D, Bektasoglu H. Relationship between intestinal microbiota and colorectal cancer. World J Gastrointest Oncol 2015; 7(10): 233-240 [PMID: 26483877 DOI: 10.4251/wjgo.v7.i10.233]
Corresponding Author of This Article
Gokhan Cipe, Associate Professor, Department of General Surgery, Fatih University, Yalı Mah. Sahil Yolu Sk. No:16, Dragos, Istanbul 34844, Turkey. gokhancipe@hotmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Oct 15, 2015; 7(10): 233-240 Published online Oct 15, 2015. doi: 10.4251/wjgo.v7.i10.233
Relationship between intestinal microbiota and colorectal cancer
Gokhan Cipe, Ufuk Oguz Idiz, Deniz Firat, Huseyin Bektasoglu
Gokhan Cipe, Department of General Surgery, Fatih University, Istanbul 34844, Turkey
Ufuk Oguz Idiz, Deniz Firat, Huseyin Bektasoglu, Department of General Surgery, Bezmialem Vakif University, Istanbul 34093, Turkey
Author contributions: Cipe G and Idiz UO contributed equally to this work; Cipe G, Idiz UO, Firat D and Bektasoglu H designed the research; Idiz UO and Firat D performed the research; Idiz UO, Firat D and Bektasoglu H wrote the paper.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Gokhan Cipe, Associate Professor, Department of General Surgery, Fatih University, Yalı Mah. Sahil Yolu Sk. No:16, Dragos, Istanbul 34844, Turkey. gokhancipe@hotmail.com
Telephone: +90-50-53743429
Received: April 29, 2015 Peer-review started: May 12, 2015 First decision: July 6, 2015 Revised: August 2, 2015 Accepted: September 7, 2015 Article in press: September 8, 2015 Published online: October 15, 2015 Processing time: 173 Days and 7.4 Hours
Abstract
The human gastrointestinal tract hosts a complex and vast microbial community with up to 1011-1012 microorganisms colonizing the colon. The gut microbiota has a serious effect on homeostasis and pathogenesis through a number of mechanisms. In recent years, the relationship between the intestinal microbiota and sporadic colorectal cancer has attracted much scientific interest. Mechanisms underlying colonic carcinogenesis include the conversion of procarcinogenic diet-related factors to carcinogens and the stimulation of procarcinogenic signaling pathways in luminal epithelial cells. Understanding each of these mechanisms will facilitate future studies, leading to the development of novel strategies for the diagnosis, treatment, and prevention of colorectal cancer. In this review, we discuss the relationship between colorectal cancer and the intestinal microbiota.
Core tip: Microbiota’s role in providing intestinal homeostasis is not as an audience, but it is active. Both the composition of microbiota and its metabolic activity impact the sensitivity of the host and can cause many pathologies including colorectal cancer.
