Case Report
Copyright ©2012 Baishideng. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2012; 4(7): 181-183
Published online Jul 15, 2012. doi: 10.4251/wjgo.v4.i7.181
Oxaliplatin induced disseminated intravascular coagulation: A case report and review of literature
Shweta Kurian, Jessica Macintyre, Muzammil Mushtaq, Caio Max Rocha-Lima, Yeon Ahn
Shweta Kurian, Jessica Macintyre, Muzammil Mushtaq, Caio Max Rocha-Lima, Yeon Ahn, Division of Hematology Oncology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, United States
Author contributions: All authors contributed to this case report.
Correspondence to: Shweta Kurian, MD, Division of Hematology Oncology, Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th ave, Suite 3300 (D8-4), Miami, FL 33136, United States. skurian@med.miami.edu
Telephone: +1-305-2431000 Fax: +1-305-2431145
Received: April 26, 2011
Revised: November 1, 2011
Accepted: November 15, 2011
Published online: July 15, 2012
Abstract

Oxaliplatin in combination with a fluoropyrimide is a treatment option for colorectal cancer patients in the adjuvant and metastatic settings. Very few hematological emergencies have been reported associated with Oxaliplatin. These include autoimmune hemolytic anemia, thrombocytopenia and pancytopenia. We present a case report of a patient who developed hematuria and disseminated intravascular coagulation while receiving the second cycle of FOLFOX and bevacizumab for metastatic colon cancer.

Keywords: Oxaliplatin; Disseminated intravascular coagulation; Hematological emergencies; Metastatic colon cancer; Platelet count