Kanno A, Satoh K, Hirota M, Hamada S, Umino J, Itoh H, Masamune A, Egawa S, Motoi F, Unno M, Ishida K, Shimosegawa T. Granular cell tumor of the pancreas: A case report and review of literature. World J Gastrointest Oncol 2010; 2(2): 121-124 [PMID: 21160931 DOI: 10.4251/wjgo.v2.i2.121]
Corresponding Author of This Article
Kennichi Satoh, MD, PhD, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aobaku, Sendai City, Miyagi 980-8574, Japan. ksatoh@mail.tains.tohoku.ac.jp
Article-Type of This Article
Case Report
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Atsushi Kanno, Kennichi Satoh, Morihisa Hirota, Shin Hamada, Jun Umino, Hiromichi Itoh, Atsushi Masamune, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aobaku, Sendai City, Miyagi 980-8574, Japan
Shinichi Egawa, Fuyuhiko Motoi, Michiaki Unno, Department of Hepatobiliary-pancreatic surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aobaku, Sendai City, Miyagi 980-8574, Japan
Kazuyuki Ishida, Department of Pathology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aobaku, Sendai City, Miyagi 980-8574, Japan
Author contributions: Kanno A and Satoh K wrote the paper; Kanno A, Satoh K, Hirota M and Masamune A identified and diagnosed the patients; Egawa S, Motoi F and Unno M performed the operation; Ishida K confirmed the pathological diagnosis; Shimosegawa T supervised and participated in the editing the manuscript; All authors read and approved the final manuscript.
Correspondence to: Kennichi Satoh, MD, PhD, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aobaku, Sendai City, Miyagi 980-8574, Japan. ksatoh@mail.tains.tohoku.ac.jp
Telephone: +81-22-7177171 Fax: +81-22-7177177
Received: August 23, 2009 Revised: November 14, 2009 Accepted: November 21, 2009 Published online: February 15, 2010
Abstract
Granular cell tumors, also called Abrikossof’s tumors, were originally described by Abrikossof A in 1926. The first case of a pancreatic granular cell tumor was described in 1975 and only 6 cases have been reported. We describe a case of granular cell tumor in the pancreas showing pancreatic duct obstruction. Because imaging studies showed findings compatible with those of pancreatic carcinoma, the patient underwent distal pancreatectomy. Histological examination showed that the tumor consisted of a nested growth of large tumor cells with ample granular cytoplasm and small round nuclei. The tumor cells expressed S-100 protein and were stained with neuron-specific enolase and periodic acid-Schiff, but were negative for desmin, vimentin, and cytokeratin. The resected tumor was diagnosed as a granular cell tumor. To our knowledge, this is the seventh case of Granular cell tumor of the pancreas to be reported.
