Three novel NEIL1 promoter polymorphisms in gastric cancer patients

doi:10.4251/wjgo.v2.i2.117

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Feb 15, 2010 (publication date) through Dec 27, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Feb 15, 2010; 2(2): 117-120
Published online Feb 15, 2010. doi: 10.4251/wjgo.v2.i2.117

Three novel NEIL1 promoter polymorphisms in gastric cancer patients

Masanori Goto, Kazuya Shinmura, Hong Tao, Shoichiro Tsugane, Haruhiko Sugimura

Masanori Goto, Kazuya Shinmura, Hong Tao, Haruhiko Sugimura, First Department of Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi Ward, Hamamatsu, Shizuoka 431-3192, Japan

Shoichiro Tsugane, Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan

Author contributions: Goto M performed the majority of the experiments; Shinmura K and Sugimura H designed the study and wrote the manuscript; Tao H performed the statistical analysis; Tsugane S coordinated the collection of all of the human materials and provided them.

Supported by Grants-in-Aid from Ministry of Health, Labour and Welfare for the Comprehensive 10-Year Strategy for Cancer Control (19-19); Japan Society for the Promotion of Science for Scientific Research, No. 19790286; Ministry of Education, Culture, Sports, Science and Technology for priority area, No. 20014007; and the 21st century COE program

Correspondence to: Haruhiko Sugimura, PhD, First Department of Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi Ward, Hamamatsu, Shizuoka 431-3192, Japan. hsugimur@hama-med.ac.jp

Telephone: +81-53-4352220 Fax: +81-53-4352225

Received: March 14, 2009
Revised: August 5, 2009
Accepted: August 12, 2009
Published online: February 15, 2010

Abstract

AIM: To identify genetic polymorphisms in the promoter region of the human base excision repair gene NEIL1 in gastric cancer patients.

METHODS: The NEIL1 promoter region in DNA from 80 Japanese patients with gastric cancer was searched for genetic polymorphisms by polymerase chain reaction-single-strand conformation polymorphism and subsequent sequencing analyses.

RESULTS: Three novel genetic polymorphisms, i.e. c.-3769C>T, c.-3170T>G, and c.-2681TA[8], were identified in the NEIL1 promoter region at an allele frequency of 0.6%, 9.4%, and 4.4%, respectively, in Japanese gastric cancer patients.

CONCLUSION: Three NEIL1 promoter polymorphisms detected in this study may be of importance in gastric carcinogenesis.

Keywords: Gastric cancer; NEIL1; Base excision repair; Genetic polymorphism