Brief Article
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World J Gastrointest Oncol. Jan 15, 2010; 2(1): 51-55
Published online Jan 15, 2010. doi: 10.4251/wjgo.v2.i1.51
Hypocaloric peripheral parenteral nutrition with lipid emulsion in postoperative gastrointestinal cancer patients
Chien-Yu Lu, Hung-Yi Chuang, Fang-Jung Yu, Li-Chu Sun, Ying-Ling Shih, Fang-Ming Chen, Jan-Sing Hsieh, Jaw-Yuan Wang
Chien-Yu Lu, Li-Chu Sun, Ying-Ling Shih, Fang-Ming Chen, Jan-Sing Hsieh, Jaw-Yuan Wang, Nutrition Support Team, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, China
Chien-Yu Lu, Fang-Jung Yu, Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, China
Hung-Yi Chuang, Community Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, China
Li-Chu Sun, Ying-Ling Shih, Department of Nursing, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, China
Fang-Ming Chen, Jan-Sing Hsieh, Jaw-Yuan Wang, Division of Gastroenterologic and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, China
Chien-Yu Lu, Department of Internal Medicine, Pingtung Hospital, Pingtung 900, Taiwan, China
Hung-Yi Chuang, School of Public Health, Kaohsiung Medical University, Kaohsiung 807, Taiwan, China
Chien-Yu Lu, Fang-Ming Chen, Jan-Sing Hsieh, Jaw-Yuan Wang, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, China
Author contributions: Lu CY designed the study, prepared for the materials and methods and analyzed the results; Chuang HY offered the idea of this study and helped in statistical analysis; Yu FJ helped conduct the literature review and personal data collection; Sun LC and Shih YL assisted in collection of cases and material preparation; Chen FM and Hsieh JS helped in protocol design and literature review; Wang JY designed and supervised the study and directed its implementation, including quality assurance and control.
Correspondence to: Jaw-Yuan Wang, MD, PhD, Professor, Division of Gastrointestinal and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, No. 100, Tz-You 1st Road, Kaohsiung 807, Taiwan, China. cy614112@ms14.hinet.net
Telephone: +886-7-3122805 Fax: +886-7-3114679
Received: February 21, 2009
Revised: July 12, 2009
Accepted: July 19, 2009
Published online: January 15, 2010
Abstract

AIM: To investigate the use of lipid emulsion substituting for glucose in postoperative hypocaloric peripheral parenteral nutrition (HPPN).

METHODS: This prospective, randomized study was conducted on 20 postoperative gastrointestinal cancer patients. They were randomized and equally divided into interventional group and control group, and both were administered isocaloric and isonitrogenous diets with for lipid emulsion substituting for partial glucose loads in the interventional group.

RESULTS: Nutritional parameters and biochemical data were compared between the two groups before and after 6-d of HPPN. Most investigated variables showed no significant changes after administration of HPPN with lipid emulsion. However, the postoperative triglyceride level was significantly lower in the interventional group than in the control group (P < 0.05). In comparison with lipid emulsion, glucose administration resulted in less decrease in postoperative prealbumin level (P < 0.05).

CONCLUSION: In addition to supplementing with essential fatty acid, it seems that HPPN with lipid emulsion is well-tolerated and beneficial to postoperative gastrointestinal cancer patients.

Keywords: Hypocaloric peripheral parenteral nutrition; Lipid emulsion; Dextrose