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World J Gastrointest Oncol. Jan 15, 2010; 2(1): 5-8
Published online Jan 15, 2010. doi: 10.4251/wjgo.v2.i1.5
Significance of biological resource collection and tumor tissue bank creation
Ying-Yan Yu, Zheng-Gang Zhu
Ying-Yan Yu, Zheng-Gang Zhu, Department of Surgery, Shanghai Institute of Digestive Surgery, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China
Author contributions: Yu YY and Zhu ZG both contributed to this paper.
Supported by Grants from the Chinese National High Tech Program, No. 863-2006AA02A402 and No. 2006AA02A301; National Natural Science Foundation of China, No. 30572127 and No. 30770961; Shanghai Pujiang Project, No. PJ200700367; and the Key Basic Research Project from Shanghai Science and Technology Commission, No. 05JC14013 and No. 09JC1409600
Correspondence to: Zheng-Gang Zhu, MD, Professor, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 200025 Shanghai, China. zzg1954@hotmail.com
Telephone: +86-21-63846590 Fax: +86-21-63846590
Received: February 1, 2009
Revised: July 4, 2009
Accepted: July 11, 2009
Published online: January 15, 2010

Progress in the molecular oncology of gastrointestinal carcinomas depends on high quality cancer tissues for research. Recent acceleration on new technological platforms as well as the “omics” revolution increases the demands on tissues and peripheral blood for research at the DNA, mRNA and protein levels. Tissue bank creation emerges as a priority. Tumor tissue banks are facilities that are organized to collect, store and distribute samples of tumor and normal tissue for further use in basic and translational cancer research. The samples are generally obtained immediately after excision, prior to fixation, to ensure optimal preservation of proteins and nucleic acids. It is possible for surgeons or pathologists to collect fresh tissue prospectively during their routine dissection procedures. Most tissue banks are “project-driven” tumor banks, which are specialized collections of tumor samples on which their research is based. Systematic collection of all available tumor tissue is much rarer. High quality tissue banks need the collaboration of clinicians and basic scientists, but also the informed consent of patients and ethical approval. Through the standard operation procedure, snap frozen fresh tissue collection, storage and quality control for cryopreserved tissues are the pivotal factors on tissue bank construction and maintaining. The purpose of the tissue bank creation is enhancing the quality and speed on both the basic and translational research on gastrointestinal cancer. The quality assurance and quality control are handled based on reviewing HE staining slides or touch imprint cytology by pathologists.

Keywords: Tissue bank, Bioresource, Cryopreservation, Quality control