Wei JR, Ouyang YN, Tang MT, Yuan JZ, Wang PL, Jiang LH, Wu LC. Charged multivesicular body protein 7 was identified as a prognostic biomarker correlated with metastasis in colorectal cancer. World J Gastrointest Oncol 2025; 17(6): 105967 [DOI: 10.4251/wjgo.v17.i6.105967]
Corresponding Author of This Article
Li-He Jiang, PhD, Professor, School of Basic Medical Sciences, Youjiang Medical University for Nationalities, No. 98 Chengxiang Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. jianglihe@ymun.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jin-Rui Wei, Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Institute of Traditional Chinese and Zhuang-Yao Ethnic Medicine Guangxi University of Chinese Medicine, Nanning 530200, Guangxi Zhuang Autonomous Region, China
Pei-Li Wang, Li-He Jiang, School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China
Li-He Jiang, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Zhejiang Shuren University, Hangzhou 310015, Zhejiang Province, China
Co-corresponding authors: Li-He Jiang and Li-Chuan Wu.
Author contributions: Wu LC and Jiang LH designed the research study and contributed equally as co-corresponding authors; Wei JR, Ouyang YN, Tang MT, Yuan JZ, and Wang PL performed the research; Wei JR and Wu LC wrote the paper.
Supported by the National Natural Science Foundation of China, No. 82260715; the Middle-Aged and Young Teachers in Colleges and Universities in Guangxi Basic Ability Promotion Project, No. 2024KY0302; Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, No. CICAR2016-P6; the Grant of Research Project on High-Level Talents of Youjiang Medical College for Nationalities, No. YY2021SK002; and Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, No. 202300011.
Institutional review board statement: As this research paper does not involve any human participants, it does not require the institutional review board statement.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets used and/or analyzed in the current study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-He Jiang, PhD, Professor, School of Basic Medical Sciences, Youjiang Medical University for Nationalities, No. 98 Chengxiang Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. jianglihe@ymun.edu.cn
Received: February 13, 2025 Revised: April 4, 2025 Accepted: May 20, 2025 Published online: June 15, 2025 Processing time: 121 Days and 11.3 Hours
Abstract
BACKGROUND
Metastasis is the main reason leading to death in colorectal cancer (CRC) and about 25% of CRC patients developed metastasis when first diagnosed. Thus, unveiling biomarkers of CRC metastasis is of great significance.
AIM
To reveal biomarkers of CRC metastasis.
METHODS
Weighted gene co-expression network analysis was conducted to identify metastatic biomarkers in CRC through a systematic analysis of the GSE29621 dataset. Comprehensive validation was performed subsequently using publicly available datasets from The Cancer Genome Atlas and Gene Expression Omnibus and supplemented with experimental verification in CRC cell lines. Moreover, the identified hub gene charged multivesicular body protein 7 (CHMP7) was further subjected to clinical correlation analysis via Kaplan-Meier survival curves and Gene Set Enrichment Analysis to assess its prognostic significance and potential mechanistic involvement in CRC progression.
RESULTS
CHMP7 was identified as a key metastatic biomarker of CRC which displayed lower expression in CRC tissues, especially in CRC patients with metastasis and CRC cell lines with high metastasis potential. The expression of CHMP7 was significantly correlated with normal, metastatic tumor, pathologic stage, and lymphatic invasion (P < 0.05). CRC patients with higher expression of CHMP7 exhibited better overall survival. Besides, Gene Set Enrichment Analysis results showed that CHMP7 might be involved in metastatic related pathways.
CONCLUSION
Our results indicate that CHMP7 might be a prognostic biomarker correlated with CRC metastasis.
Core Tip: Tumor metastasis is the main reason leading to death in colorectal cancer (CRC). Unveiling CRC metastasis related biomarkers is of great significance. In this study, charged multivesicular body protein 7 (CHMP7) was identified as a prognostic factor correlated with metastasis in CRC. CHMP7 showed a lower expression in CRC patients with metastasis and CRC cell lines with high metastasis potential. The expression of CHMP7 was significantly correlated with normal, metastatic tumor, pathologic stage, and lymphatic invasion (P < 0.05). CRC patients with higher expression of CHMP7 exhibited better overall survival. Besides, Gene Set Enrichment Analysis results showed that CHMP7 might be involved in metastatic related pathways.
