Snail family transcriptional repressor 1 radiosensitizes esophageal cancer via epithelial-mesenchymal transition signaling: From bioinformatics to integrated study
Xiao-Li Lv, Qi-Liang Peng, Xin-Peng Wang, Zhi-Chao Fu, Jian-Ping Cao, Jian Wang, Li-Li Wang, Yang Jiao
Xiao-Li Lv, Jian-Ping Cao, Yang Jiao, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, Jiangsu Province, China
Xiao-Li Lv, Li-Li Wang, Department of Radiotherapy, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
Qi-Liang Peng, Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China
Xin-Peng Wang, Zhi-Chao Fu, Department of Radiotherapy, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou 350112, Fujian Province, China
Jian Wang, Department of Radiotherapy, The Affiliated Jiangyin People’s Hospital of Nantong University, Jiangyin 214400, Jiangsu Province, China
Co-first authors: Xiao-Li Lv and Qi-Liang Peng.
Co-corresponding authors: Li-Li Wang and Yang Jiao.
Author contributions: Lv XL and Jiao Y conceptualized and designed the research; Peng QL, Wang XP, and Fu ZC screened patients, acquired clinical data, and contributed to database mining and bioinformatics analysis; Cao JP and Li HY provided project resources and oversaw project management; Lv XL conducted all cellular and animal experiments; Lv XL, Peng QL, Wang LL, and Jiao Y performed data analysis; Lv XL, Wang LL, and Jiao Y wrote the manuscript; All authors have read and approved the final manuscript. Both Lv XL and Peng QL made substantial and indispensable contributions to the conceptualization, investigation, and execution of the project and are designated as co-first authors. Lv XL played a central role in designing the research, performing cellular and animal experiments, analyzing the data, and preparing the first draft of the manuscript. Peng QL contributed significantly to patient screening, clinical data acquisition, database mining, bioinformatics analysis, and data interpretation, making their contributions equally vital. Both Wang LL and Jiao Y made critical and indispensable contributions as co-corresponding authors. Wang LL provided essential guidance for methodology development, conducted comprehensive reviews, and contributed to manuscript refinement. Jiao Y supervised the overall project, provided critical resources, and led the refinement and submission of the manuscript with a focus on data interpretation and the broader implications of the findings. Their collaboration has been instrumental in the successful completion and publication of this research.
Supported by the National Key R&D Program of China, No. 2022YFC2503700 and No. 2022YFC2503703; and the National Health Commission Key Laboratory of Nuclear Technology Medical Transformation (Mianyang Central Hospital), No. 2023HYX005.
Institutional review board statement: This clinical research study involving human participants has received ethical approval from the Ethics Committee of the Second Affiliated Hospital of Soochow University (Approval No: JD-LX-2020-059-02, Approval Date: September 4, 2020). All patients participating in this study have provided written informed consent after being thoroughly informed about the study objectives, procedures, potential risks, and benefits.
Institutional animal care and use committee statement: The current investigation received approval from the Ethics Committee of Soochow University (approval no. SUDA20221024A02) and was conducted in accordance with the guidelines of the Committee on Animal Research and Ethics.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: Data supporting the findings of this study are available upon reasonable request from the corresponding author at
jiaoyang@suda.edu.cn.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Yang Jiao, PhD, Professor, State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, No. 199 Ren'ai Road, Suzhou Industrial Park, Suzhou 215123, Jiangsu Province, China.
jiaoyang@suda.edu.cn
Received: June 4, 2024
Revised: December 9, 2024
Accepted: January 15, 2025
Published online: April 15, 2025
Processing time: 293 Days and 20.8 Hours
