Yi AQ, Xie GH. Pancreatic neuroendocrine neoplasms coexisting with biliary intraductal papillary mucinous neoplasm: A case report and review of literature. World J Gastrointest Oncol 2025; 17(4): 100497 [DOI: 10.4251/wjgo.v17.i4.100497]
Corresponding Author of This Article
Guang-Hua Xie, Department of Hepatobiliary Surgery, Yanbian University Affiliated Hospital, No. 1327 Juzi Street, Yanji 133099, Jilin Province, China. ghxie@ybu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Apr 15, 2025; 17(4): 100497 Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.100497
Pancreatic neuroendocrine neoplasms coexisting with biliary intraductal papillary mucinous neoplasm: A case report and review of literature
An-Qi Yi, Guang-Hua Xie
An-Qi Yi, Guang-Hua Xie, Department of Hepatobiliary Surgery, Yanbian University Affiliated Hospital, Yanji 133099, Jilin Province, China
Author contributions: Yi AQ and Xie GH designed the study and wrote the manuscript; Yi AQ performed the experiments; Xie GH analyzed the data; and both authors reviewed and approved the final version of the manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guang-Hua Xie, Department of Hepatobiliary Surgery, Yanbian University Affiliated Hospital, No. 1327 Juzi Street, Yanji 133099, Jilin Province, China. ghxie@ybu.edu.cn
Received: August 19, 2024 Revised: December 6, 2024 Accepted: February 25, 2025 Published online: April 15, 2025 Processing time: 218 Days and 9.4 Hours
Abstract
BACKGROUND
Pancreatic neuroendocrine neoplasms (pNENs) are rare, heterogeneous tumors accounting for 1%-2% of pancreatic tumors, with significant malignant potential. Intraductal papillary mucinous neoplasm of the bile duct (IPMN-B) is a rare precancerous lesion in the bile duct system, with potential for malignancy. The combination of pNENs and IPMN-B is exceptionally rare and often leads to misdiagnosis. This study aims to report a rare case of pNENs combined with IPMN-B treated at Yanbian University Hospital to improve understanding and management of this unusual tumor combination.
CASE SUMMARY
We retrospectively analyzed a case from Yanbian University Hospital. We reviewed clinical records, imaging findings, endoscopic retrograde cholangiopancreatography, surgical exploration, and histopathological examination. The patient was diagnosed with pNENs and IPMN-B. Surgical treatment was performed, with follow-up showing effective management and no significant recurrence.
CONCLUSION
This case represents the first report of pNENs combined with IPMN-B. It highlights the need for thorough diagnostic evaluation to prevent misdiagnosis and improve treatment strategies.
Core Tip: This case report presents the first documented instance of pancreatic neuroendocrine neoplasms coexisting with intraductal papillary mucinous neoplasm of the bile duct. The study highlights the importance of comprehensive diagnostic evaluation to distinguish between these two rare entities, which are often misdiagnosed. By detailing the diagnostic and therapeutic approaches taken, this report offers new insights into managing this unusual tumor combination, underscoring the need for heightened awareness and careful consideration in similar cases.
