Ren MJ, Zhang ZL, Tian C, Liu GQ, Zhang CS, Yu HB, Xin Q. Importance of early detection in multiple endocrine neoplasia type 1: Clinical insights and future directions. World J Gastrointest Oncol 2025; 17(4): 100013 [DOI: 10.4251/wjgo.v17.i4.100013]
Corresponding Author of This Article
Qi Xin, PhD, Chief Physician, Department of Pathology, Tianjin Third Center Hospital, No. 83 Jintang Road, Tianjin 300170, China. xinqi19820204@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mei-Jing Ren, Can Tian, Gui-Qiu Liu, Chuan-Shan Zhang, Qi Xin, Department of Pathology, Tianjin Third Center Hospital, Tianjin 300170, China
Zi-Li Zhang, Department of Gastrointestinal Surgery, Tianjin Third Center Hospital, Tianjin 300170, China
Hai-Bo Yu, Department of Laboratory, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
Co-first authors: Mei-Jing Ren and Zi-Li Zhang.
Co-corresponding authors: Qi Xin and Hai-Bo Yu.
Author contributions: Xin Q and Yu HB conceptualized and designed the research; Ren MJ and Zhang ZL contributed to data collection; Xin Q contributed to the pathological analysis; Zhang ZL and Yu HB contributed to the clinical features analysis; Ren MJ, Tian C, Yu HB, Liu GQ and Zhang CS contributed to revision of the manuscript; All the authors have read and approved the final manuscript. Both authors have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper. Both Xin Q and Yu HB have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors. Xin Q applied for and obtained the funds for this research project. Yu HB conceptualized, designed, and supervised the whole process of the project. He conducted a literature search, revised and addressed the issues raised by the reviewers, and summarized the latest research progress. This collaboration between Xin Q and Yu HB is crucial for the publication of this manuscript.
Supported by Tianjin Third Central Hospital, No. 2019YNR3.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi Xin, PhD, Chief Physician, Department of Pathology, Tianjin Third Center Hospital, No. 83 Jintang Road, Tianjin 300170, China. xinqi19820204@126.com
Received: August 5, 2024 Revised: January 11, 2025 Accepted: February 18, 2025 Published online: April 15, 2025 Processing time: 232 Days and 6.3 Hours
Abstract
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-inherited syndrome involving multiple endocrine tumors. It is characterized by multiple mutations in the tumor suppressor gene MEN1, which is located on chromosome 11q13. As main etiology of MEN1 is genetic mutations, clinical symptoms may vary. In this editorial, we comment on the article by Yuan et al. This article describes a case of (MEN1) characterized by low incidence and diagnostic complexity. MEN1 commonly presents as parathyroid, pancreatic, and pituitary tumors. Diagnosis requires a combination of serologic tests, magnetic resonance imaging, computed tomography, endoscopic ultrasonography, immunologic and pathology. The diagnosis is unique depending on the site of disease. Surgical resection is the treatment of choice for MEN1. The prognosis depends on the site of origin, but early detection and intervention is the most effective.
Core Tip: Multiple endocrine neoplasia is a rare syndrome in which tumors occur simultaneously or sequentially in multiple endocrine organs. It is important to identify potential patients early and conduct multiple examinations, including biochemical multitype and multisite imaging examinations, according to the disease spectrum of each type. This emphasizes the need for a multidisciplinary approach to help achieve an accurate diagnosis and effective treatment.
