Liu GJ, Long XY, Zhang F, Ren T, Xia X. Heterochronic gastric adenosquamous carcinoma combined with colonic adenoma: A case report. World J Gastrointest Oncol 2025; 17(3): 101734 [DOI: 10.4251/wjgo.v17.i3.101734]
Corresponding Author of This Article
Xun Xia, MD, Chief Doctor, Neurosurgeon, Professor, Department of Neurosurgery, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, No. 278 Baoguang Road, Xindu District, Chengdu 610500, Sichuan Province, China. xiaxun@cmc.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Mar 15, 2025; 17(3): 101734 Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.101734
Heterochronic gastric adenosquamous carcinoma combined with colonic adenoma: A case report
Gui-Jiang Liu, Xiao-Yi Long, Fei Zhang, Tao Ren, Xun Xia
Gui-Jiang Liu, Fei Zhang, Xun Xia, Department of Neurosurgery, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan Province, China
Xiao-Yi Long, Department of Pathology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan Province, China
Tao Ren, Department of Oncology, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Sichuan Province, China
Co-corresponding authors: Tao Ren and Xun Xia.
Author contributions: Liu GJ, Long XY, and Zhang F collected data and knowledge concepts; Liu GJ wrote manuscript; Long XY edited manuscripts; Ren T and Xia X are responsible for obtaining and managing project funds, they contributed equally as co-corresponding authors; and all authors approved the final version of the manuscript.
Supported by Scientific Research Fund of Sichuan Health and Wellness, China, No. 21PJ113.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xun Xia, MD, Chief Doctor, Neurosurgeon, Professor, Department of Neurosurgery, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, No. 278 Baoguang Road, Xindu District, Chengdu 610500, Sichuan Province, China. xiaxun@cmc.edu.cn
Received: September 25, 2024 Revised: November 12, 2024 Accepted: December 23, 2024 Published online: March 15, 2025 Processing time: 142 Days and 8.2 Hours
Abstract
BACKGROUND
Metachronous gastric cancer usually refers to a tumor that occurs in the stomach more than half a year after esophageal cancer surgery, and metastasis of primary esophageal cancer should be excluded. There are few reports of metachronous gastric adenosquamous carcinoma with signet ring cell carcinoma combined with early tubular adenoma of the colon after esophageal cancer surgery, which has a high degree of malignancy. This is also the reason for the poor treatment results.
CASE SUMMARY
A 54-year-old male patient was admitted to the hospital with “dysphagia obstruction”. Seven years ago, the patient was diagnosed with well-differentiated squamous cell carcinoma in the middle esophagus (T4N1M0 stage) and left gastric lymph node metastasis. In the final resection of the esophageal cancer, no residual cancer tissue was found in the esophageal and gastric stump. The patient’s medical history 7 years ago (preoperative gastroscopy and other examinations) revealed no gastric tumor. Combined with the patient’s history, the diagnosis of recurrent esophageal cancer was made on this admission. The final pathological results were surprising: Metachronous gastric adenosquamous carcinoma with signet ring cell carcinoma combined with early tubular adenoma of the colon. Considering the high malignancy of the tumor, the complexity of the second operation, and many complications, the patient received chemotherapy.
CONCLUSION
He had a history of esophageal cancer resection. Gastroenteroscopy should be performed simultaneously to avoid missed diagnosis and misdiagnosis.
Core Tip: The common type of gastric cancer is adenocarcinoma, but the pathological type of gastric adenosquamous carcinoma is rare, so metachronous gastric adenosquamous carcinoma with signet ring cell carcinoma is even rarer. The metachronous tumors after esophageal cancer surgery are mostly found in the stomach, head and neck, but those occurring in the stomach and distal colon at the same time are rare.
