Lin QN, Wu Q, Lv C, Tang J, Zhao LY, Xu KY. Potential role of coagulation markers in early detection of bone metastasis in gastric cancer: A critical review. World J Gastrointest Oncol 2025; 17(3): 100292 [DOI: 10.4251/wjgo.v17.i3.100292]
Corresponding Author of This Article
Ke-Yang Xu, Assistant Professor, MD, PhD, Faculty of Chinese Medicine, and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wailong, Taipa, Macau 999078, China. 21482055@life.hkbu.edu.hk
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Qing-Nan Lin, School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Qing-Nan Lin, Chong Lv, Jun Tang, Department of Orthopedics, Wuyi County Traditional Chinese Medicine Hospital, Jinhua 321200, Zhejiang Province, China
Qian Wu, Operating Room, Wuyi County Traditional Chinese Medicine Hospital, Jinhua 321200, Zhejiang Province, China
Ling-Yun Zhao, Ke-Yang Xu, Faculty of Chinese Medicine, and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China
Ke-Yang Xu, Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
Co-first authors: Qing-Nan Lin and Qian Wu.
Author contributions: Lin QN and Xu KY designed the research study; Lin QN and Wu Q wrote the manuscript; Lin QN, Wu Q, Lv C, Tang J, Zhao LY and Xu KY revised the manuscript; All authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare they have no conflicts of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ke-Yang Xu, Assistant Professor, MD, PhD, Faculty of Chinese Medicine, and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wailong, Taipa, Macau 999078, China. 21482055@life.hkbu.edu.hk
Received: August 13, 2024 Revised: November 26, 2024 Accepted: December 17, 2024 Published online: March 15, 2025 Processing time: 185 Days and 1.4 Hours
Abstract
This letter to the editor involves the article published in the World Journal of Gastrointestinal Oncology. Bone metastasis (BM) in gastric cancer (GC) is uncommon but can be prevalent in autopsy studies. BM significantly impairs quality of life and is frequently underdiagnosed, as sensitive diagnostic tests are only performed after symptoms occur. Imaging is crucial for the diagnosis of BM but is not routinely used for screening and is expensive. Examining laboratory risk factors for BM in GC patients using multivariate analysis could be a more effective approach.
Core Tip: This letter aims to highlight the potential of tests for coagulation markers as cost-effective, non-invasive tools for early detection of bone metastasis in gastric cancer patients. To enhance the study's applicability, it is crucial to clarify patient grouping criteria and imaging methodologies. Additionally, incorporating diverse, multi-center cohorts and exploring a broader range of biomarkers may strengthen the findings of previous studies. Future research should also consider the impact of treatment on biomarker levels and the underlying mechanisms of hypercoagulability in metastasis to improve patients’ outcomes.
