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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Association between autoimmune gastritis and gastric polyps: Clinical characteristics and risk factors
Jing-Zheng Jin, Xiao Liang, Shu-Peng Liu, Rui-Lan Wang, Qing-Wei Zhang, Yu-Feng Shen, Xiao-Bo Li
Jing-Zheng Jin, Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Jing-Zheng Jin, Xiao Liang, Shu-Peng Liu, Qing-Wei Zhang, Yu-Feng Shen, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Diseases, Shanghai 200001, China
Xiao Liang, Shu-Peng Liu, Qing-Wei Zhang, Division of Gastroenterology and Hepatology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Rui-Lan Wang, Division of Gastroenterology and Hepatology, Sichuan Armed Police Corps Hospital, Leshan 610041, Sichuan Province, China
Yu-Feng Shen, Division of Gastroenterology and Hepatology, NHC Key Laboratory of Digestive Diseases, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Xiao-Bo Li, Department of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive Diseases, Shanghai 200127, China
Co-first authors: Jing-Zheng Jin and Xiao Liang.
Co-corresponding authors: Yu-Feng Shen and Xiao-Bo Li.
Author contributions: Jin JZ, Liang X, and Liu SP contributed equally to this research, Jin JZ and Liang X are the co-first authors of this manuscript. Jin JZ and Liang X conceptualized the study and authored the manuscript; Liu SP played a key role in designing the analysis plans; Wang RL were responsible for data collection and provided technical support throughout the research; Zhang QW, Shen YF, and Li XB also made equal contributions to the study; Zhang QW, Shen YF, and Li XB meticulously reviewed, proofread the manuscript, and suggested valuable improvements, they are the co-corresponding authors of this manuscript. All authors reviewed and approved the final version of the manuscript.
Supported by the Health Technology Project of Pudong New District Health Commission, No. PW2020D-12.
Institutional review board statement: This study received approval from the Institutional Ethics Committee of Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Approval No. LY2024-141-B.
Informed consent statement: The informed consent was waived by the Institutional Ethics Committee of Renji Hospital, Shanghai Jiao Tong University, School of Medicine.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Xiao-Bo Li, MD, PhD, Doctor, Professor, Department of Gastro
enterology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive Diseases, No. 160 Pujian Road, Pudong New Area, Shanghai 200127, China.
lxb196911@163.com
Received: February 10, 2024
Revised: August 23, 2024
Accepted: September 11, 2024
Published online: January 15, 2025
Processing time: 306 Days and 4.2 Hours
BACKGROUND
The relationship between autoimmune gastritis (AIG) and gastric polyps (GPs) is not well understood.
AIM
To explore the clinical characteristics and risk factors of AIG with GPs in patients.
METHODS
This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July 2023. We collected clinical, biochemical, serological, and demographic data were of each patient. Logistic regression analyses, both multivariate and univariate, were conducted to pinpoint independent risk factors for GPs in patients with AIG patients. Receiver operating characteristic curves were utilized to establish the optimal cutoff values, sensitivity, and specificity of these risk factors for predicting GPs in patients with AIG.
RESULTS
Patients with GPs had a higher median age than those without GPs [61 (52.25-69) years vs 58 (47-66) years, P = 0.006]. The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs [91.9 (34.2-138.9) pmol/mL vs 60.9 (12.6-98.4) pmol/mL, P < 0.001]. Additionally, the positive rate of parietal cell antibody (PCA) antibody was higher in these patients than in those without GPs (88.6% vs 73.6%, P < 0.001). Multivariate and univariate analyses revealed that PCA positivity [odds ratio (OR) = 2.003, P = 0.017], pepsinogen II (OR = 1.053, P = 0.015), and enterochromaffin like cells hyperplasia (OR = 3.116, P < 0.001) were significant risk factors for GPs, while pepsinogen I was identified as a protective factor.
CONCLUSION
PCA positivity and enterochromaffin like cells hyperplasia are significant risk factor for the development of GPs in patients with AIG. Elevated gastrin-17 levels may also play a role in this process. These findings suggest potential targets for further research and therapeutic intervention in managing GPs in patients with AIG.
Core Tip: In this double-center retrospective study, we explore the clinical characteristics and risk factors associated with autoimmune gastritis (AIG) and gastric polyps in 530 patients diagnosed with AIG from July 2019 to July 2023. The study found that higher age, elevated gastrin-17 levels, and higher positivity rates of parietal cell antibody antibodies were significantly associated with the presence of gastric polyps in AIG patients. Through univariate and multivariate analyses, parietal cell antibody positivity, elevated pepsinogen II levels, and enterochromaffin like cells hyperplasia were identified as significant risk factors.
