Wei XY, Cao WB, Mo SJ, Sun ZY. Curcumin in gastric cancer treatment: A commentary on mechanistic insights and future directions. World J Gastrointest Oncol 2025; 17(1): 100369 [DOI: 10.4251/wjgo.v17.i1.100369]
Corresponding Author of This Article
Sai-Jun Mo, PhD, Associate Professor, Department of Basic Science of Oncology, School of Basic Medical Sciences, Zhengzhou University, No. 100 Science Avenue, Zhongyuan District, Zhengzhou 450001, Henan Province, China. sjmo@zzu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jan 15, 2025; 17(1): 100369 Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.100369
Curcumin in gastric cancer treatment: A commentary on mechanistic insights and future directions
Xin-Yue Wei, Wen-Bo Cao, Sai-Jun Mo, Zhi-Yan Sun
Xin-Yue Wei, Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Wen-Bo Cao, School of Basic Medical Science, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Sai-Jun Mo, Department of Basic Science of Oncology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Zhi-Yan Sun, Department of Special Service, No. 988 Hospital of the Joint Service Support Force of PLA, Zhengzhou 450042, Henan Province, China
Co-first authors: Xin-Yue Wei and Wen-Bo Cao.
Co-corresponding authors: Sai-Jun Mo and Zhi-Yan Sun.
Author contributions: This study was conceptualized and the draft was written by Wei XY; Cao WB, Mo SJ, and Sun ZY participated in revising the manuscript; All authors have read and approved the final version of the manuscript. Wei XY proposed the study, designed and performed the analysis, and wrote the initial draft. Cao WB was responsible for proofreading and editing. Both authors made key and indispensable contributions to the completion of this project and are, therefore, eligible to be co-first authors thereof. Mo SJ and Sun ZY served as co-corresponding authors and played an important and indispensable role in various aspects, including writing the paper. Mo SJ applied for and obtained funding for this research project; she supervised the entire process of the project, searched for relevant materials, and revised and submitted the early versions of the manuscript. The collaboration between Mo SJ and Sun ZY was crucial for the publication of this manuscript and other manuscripts currently in preparation.
Supported by The College Students’ Innovation and Entrepreneurship Competition, No. 2024cxcy504 and No. 202410459164.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sai-Jun Mo, PhD, Associate Professor, Department of Basic Science of Oncology, School of Basic Medical Sciences, Zhengzhou University, No. 100 Science Avenue, Zhongyuan District, Zhengzhou 450001, Henan Province, China. sjmo@zzu.edu.cn
Received: August 14, 2024 Revised: September 23, 2024 Accepted: October 21, 2024 Published online: January 15, 2025 Processing time: 119 Days and 21 Hours
Abstract
The study by Yang et al presents a comprehensive investigation into the therapeutic potential of curcumin for gastric cancer (GC). Using network pharmacology, the researchers identified 48 curcumin-related genes, 31 of which overlap with GC targets. Key genes, including ESR1, EGFR, CYP3A4, MAPK14, CYP1A2, and CYP2B6, are linked to poor survival in GC patients. Molecular docking confirmed strong binding affinity of curcumin to these genes. In vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823, suggesting its therapeutic potential in GC through multiple targets and pathways.
Core Tip: The study by Yang et al elucidates the therapeutic mechanisms of curcumin in gastric cancer treatment, identifying key targets and confirming their interactions with curcumin through molecular docking. This study provides a solid foundation for further exploration of curcumin’s role in gastric cancer therapy.
