Li HM, Liu Y, Hao MD, Liang XQ, Yuan DJ, Huang WB, Li WJ, Ding L. Research status and hotspots of tight junctions and colorectal cancer: A bibliometric and visualization analysis. World J Gastrointest Oncol 2024; 16(8): 3705-3715 [PMID: 39171170 DOI: 10.4251/wjgo.v16.i8.3705]
Corresponding Author of This Article
Lei Ding, MD, Chief Doctor, Department of Gastrointestinal Oncology Surgery, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyilu, Yangfangdian, Haidian District, Beijing 100038, China. dinglei1005@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Scientometrics
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Hui-Min Li, Yin Liu, Meng-Di Hao, Xiao-Qing Liang, Da-Jin Yuan, Wen-Bin Huang, Wen-Jie Li, Lei Ding, Department of Gastrointestinal Oncology Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Author contributions: Li HM contributed to the conception and design of the study, and drafted and revised the manuscript; Liu Y and Hao MD are responsible for literature searching and data collection; Liang XQ and Yuan DJ are responsible for statistical analysis and charting; Huang WB and Li WJ checked the manuscript for grammar and spelling; Ding L coordinated the design and facilities for this study, provided multiple support in terms of personnel, materials and methods for the conduct of this study. All authors all approved the final manuscript.
Supported bythe National Natural Science Foundation of China, No. 82170525; and Beijing Shijitan Hospital Professionals Training Program, No. 2023 LJRCDL.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei Ding, MD, Chief Doctor, Department of Gastrointestinal Oncology Surgery, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyilu, Yangfangdian, Haidian District, Beijing 100038, China. dinglei1005@126.com
Received: May 7, 2024 Revised: June 11, 2024 Accepted: July 1, 2024 Published online: August 15, 2024 Processing time: 93 Days and 2.1 Hours
Abstract
BACKGROUND
Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death. Over the past two decades, numerous researchers have provided important evidence regarding the role of tight junction (TJ) proteins in the occurrence and progression of CRC. The causal relationship between the presence of specific TJ proteins and the development of CRC has also been confirmed. Despite the large number of publications in this field, a bibliometric study to review the current state of research and highlight the research trends and hotspots in this field has not yet been performed.
AIM
To analyze research on TJs and CRC, summarize the field’s history and current status, and predict future research directions.
METHODS
We searched the Science Citation Index Expanded database for all literature on CRC and TJs from 2001-2023. We used bibliometrics to analyze the data of these papers, such as the authors, countries, institutions, and references. Co-authorship, co-citation, and co-occurrence analyses were the main methods of analysis. CiteSpace and VOSviewer were used to visualize the results.
RESULTS
A total of 205 studies were ultimately identified. The number of publications on this topic has steadily increased since 2007. China and the United States have made the largest contributions to this field. Anticancer Research was the most prolific journal, publishing 8 articles, while the journal Oncogene had the highest average citation rate (68.33). Professor Dhawan P was the most prolific and cited author in this field. Co-occurrence analysis of keywords revealed that “tight junction protein expression”, “colorectal cancer”, “intestinal microbiota”, and “inflammatory bowel disease” had the highest frequency of occurrence, revealing the research hotspots and trends in this field.
CONCLUSION
This bibliometric analysis evaluated the scope and trends of TJ proteins in CRC, providing valuable research perspectives and future directions for studying the connection between the two. It is recommended to focus on emerging research hotspots, such as the correlations among intestinal microbiota, inflammatory bowel disease, TJ protein expression, and CRC.
Core Tip: This bibliometric analysis evaluated the scope and trends of tight junction (TJ) proteins in colorectal cancer (CRC), providing valuable research perspectives and future directions for studying the connection between the two. It is recommended to focus on emerging hotspots such as the correlations among intestinal microbiota, inflammatory bowel disease, TJ protein expression, and CRC.
