Wan DD, Li XJ, Wang XR, Liu TX. Metachronous multifocal carcinoma: A case report. World J Gastrointest Oncol 2024; 16(7): 3350-3356 [PMID: 39072183 DOI: 10.4251/wjgo.v16.i7.3350]
Corresponding Author of This Article
Xiao-Ju Li, MD, Professor, Department of Hepatobiliary Surgery, Qujing Second People’s of Yunnan Province, No. 256 Qilin Xi Street, Qilin District, Qujing 655000, Yunnan Province, China. 1520179896@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jul 15, 2024; 16(7): 3350-3356 Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.3350
Metachronous multifocal carcinoma: A case report
Dan-Dan Wan, Xiao-Ju Li, Xing-Ru Wang, Tian-Xi Liu
Dan-Dan Wan, School of Clinical Medicine, Qujing Medical College, Qujing 655000, Yunnan Province, China
Xiao-Ju Li, Department of Hepatobiliary Surgery, Qujing Second People’s of Yunnan Province, Qujing 655000, Yunnan Province, China
Xing-Ru Wang, Institute of Hepatobiliary Surgery, The First Affiliated Hospital, Army Medical University, Chongqing 400038, China
Tian-Xi Liu, Department of Hepatobiliary Surgery, Qujing Central Hospital of Yunnan Regional Medical Center, Qujing 655000, Yunnan Province, China
Author contributions: Wan DD and Wang XR contributed to the conceptualization, writing of the original draft, and critical revision of this manuscript; Li XJ and Liu TX participated in the writing, review, operation, and editing of this article.
Supported bythe Education Project of Yunnan Province, No. 2023J767; and the High-level Talent Training Support Project of Yunnan Province, No. YNWR-MY-2020-053.
Informed consent statement: Study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Ju Li, MD, Professor, Department of Hepatobiliary Surgery, Qujing Second People’s of Yunnan Province, No. 256 Qilin Xi Street, Qilin District, Qujing 655000, Yunnan Province, China. 1520179896@qq.com
Received: March 31, 2024 Revised: May 6, 2024 Accepted: May 21, 2024 Published online: July 15, 2024 Processing time: 103 Days and 3.3 Hours
Abstract
BACKGROUND
The incidence of multiple primary carcinomas (MPC) varies greatly, ranging from 0.73% to 11.70% in foreign countries, with duo-duplex carcinoma being the most common, trio-duplex carcinoma and above being rare, and simultaneous multigenic carcinoma being even rarer, accounting for 18.4% to 25.3% of the incidence of MPC. However, there is no report regarding patients presenting with simultaneous dual-origin carcinoma of the liver and colon and heterochronous pancreatic cancer.
CASE SUMMARY
We report a special case of multifocal carcinoma, in which one patient had a medical condition of primary liver and colon cancer and pancreatic cystadenocarcinoma 2 years after surgery. Through aggressive advanced fluorescent laparoscopic techniques, standardized immunotherapy, targeting, and chemotherapy, a better prognosis and a desirable survival period were achieved for the patient.
CONCLUSION
There is a need to clarify the nature of MPC through advanced surgical means to ensure better diagnosis and treatment.
Core Tip: This study describes an uncommon case of simultaneous dual-origin carcinoma of the liver and colon and heterochronous pancreatic cancer, which was verified through histopathological and immunohistochemical analyses. Our findings suggest that patients can benefit from comprehensive diagnosis and treatment.
