Zhao GG, Lou C, Gao RL, Lei FX, Zhao J. Combined use of dexmedetomidine and nalbuphine in laparoscopic radical gastrectomy for gastric cancer. World J Gastrointest Oncol 2024; 16(7): 2952-2959 [PMID: 39072152 DOI: 10.4251/wjgo.v16.i7.2952]
Corresponding Author of This Article
Jing Zhao, BSc, Nurse, Department of Dermatology, The Second Affiliated Hospital of Shandong First Medical University, No. 706 Mount Taishan Street, Daiyue District, Tai’an 271000, Shandong Province, China. 15662019899@163.com
Research Domain of This Article
Anesthesiology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Guo-Guang Zhao, Chao Lou, Rong-Lei Gao, Fu-Xing Lei, Department of Anesthesiology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an 271000, Shandong Province, China
Jing Zhao, Department of Dermatology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an 271000, Shandong Province, China
Co-first authors: Guo-Guang Zhao and Chao Lou.
Author contributions: Zhao GG and Lou C, as co-first authors, jointly completed the design and research of this paper; Gao RL and Lei FX performed the research; Zhao GG and Zhao J analyzed the data and wrote the manuscript; and all authors have read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the institutional review board of The Second Affiliated Hospital of Shandong First Medical University.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: The data are available from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Zhao, BSc, Nurse, Department of Dermatology, The Second Affiliated Hospital of Shandong First Medical University, No. 706 Mount Taishan Street, Daiyue District, Tai’an 271000, Shandong Province, China. 15662019899@163.com
Received: February 26, 2024 Revised: April 24, 2024 Accepted: May 13, 2024 Published online: July 15, 2024 Processing time: 137 Days and 14.5 Hours
Abstract
BACKGROUND
Radical laparoscopic gastrectomy is an important treatment modality for gastric cancer. Surgery requires general anesthesia, and patients are susceptible to the effects of anesthetic drugs and carbon dioxide insufflation during the procedure, leading to inflammation or severe pain, which can affect patient outcome.
AIM
To explore the efficacy of combining dexmedetomidine (DEX) with nalbuphine in patients underwent laparoscopic radical gastrectomy for gastric cancer.
METHODS
Patients scheduled to undergo laparoscopic radical gastrectomy were selected and randomly assigned to A or B group. In A group, patients received an intravenous injection of nalbuphine 0.2 mg/kg + DEX 0.4 μg/kg 10 min before the end of surgery; in B group, patients received only an intravenous injection of nalbuphine. The trends in hemodynamic parameter fluctuations, awakening quality during the recovery period, serum inflammatory markers, agitation scores, cough severity, incidence, and duration of postoperative delirium (POD) were compared.
RESULTS
The mean arterial pressure and heart rate in the A group were more stable (P < 0.05). The A group had a lower average awakening time, extubation time, and agitation scores during recovery than the B group. Agitation control in the A group was more effective at different time points (P < 0.05). Patients in the A group had lower serum interleukin (IL)-6, tumour necrosis factor alpha, and IL-10 levels at 1 h after surgery than the B group. The incidence of coughing and duration of POD were lower and shorter in the A group than in the B group. Adverse reactions caused by the two anesthesia methods were less frequent in the A group than in the B group (P < 0.05).
CONCLUSION
The use of DEX and nalbuphine in patients undergoing laparoscopic radical gastrectomy for gastric cancer help reducing the inflammatory response, cough severity, and agitation and helps maintain hemodynamic stability.
Core Tip: This study analyzed the effects of dexmedetomidine combined with nalbuphine on the quality and effect of anesthesia in patients undergoing laparoscopic radical gastrectomy for gastric cancer, in order to provide clinical reference.
