Wang G, Liu T, He WT. Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids. World J Gastrointest Oncol 2024; 16(6): 2826-2841 [DOI: 10.4251/wjgo.v16.i6.2826]
Corresponding Author of This Article
Wen-Ting He, Doctor, Associate Professor, The Second Hospital & Clinical Medical School, Lanzhou University, No. 82 Cuiyingmen, Chengguan District, Lanzhou 730030, Gansu Province, China. hewt@lzu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Scientometrics
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2826-2841 Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2826
Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids
Gang Wang, Tao Liu, Wen-Ting He
Gang Wang, Tao Liu, Wen-Ting He, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China
Gang Wang, Tao Liu, Wen-Ting He, Digestive System Tumor Prevention and Treatment and Translational Medicine Engineering Innovation Center of Lanzhou University, Lanzhou University, Lanzhou 730000, Gansu Province, China
Gang Wang, Tao Liu, Wen-Ting He, Digestive System Tumor Translational Medicine Engineering Research Center of Gansu Province, Lanzhou University, Lanzhou 730000, Gansu Province, China
Tao Liu, Wen-Ting He, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, Gansu Province, China
Author contributions: Wang G wrote the paper; He WT and Liu T reviewed the literature and designed the outline and coordinated the writing of the paper; All the authors have read and agreed to the published version of the manuscript. Liu T and He WT contributed equally to this work as co-corresponding authors. The designation of co corresponding authors reflects the relevant responsibilities and task distribution for completing the research, as well as our team spirit of cooperation. This promotes comprehensive research on the research topic.
Supported byThe Science and Technology Program of Gansu Province, No. 23JRRA1015.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Ting He, Doctor, Associate Professor, The Second Hospital & Clinical Medical School, Lanzhou University, No. 82 Cuiyingmen, Chengguan District, Lanzhou 730030, Gansu Province, China. hewt@lzu.edu.cn
Received: December 24, 2023 Revised: March 9, 2024 Accepted: April 19, 2024 Published online: June 15, 2024 Processing time: 173 Days and 9.1 Hours
Abstract
BACKGROUND
Gastrointestinal tumor organoids serve as an effective model for simulating cancer in vitro and have been applied in basic biology and preclinical research. Despite over a decade of development and increasing research achievements in this field, a systematic and comprehensive analysis of the research hotspots and future trends is lacking.
AIM
To address this problem by employing bibliometric tools to explore the publication years, countries/regions, institutions, journals, authors, keywords, and references in this field.
METHODS
The literature was collected from Web of Science databases. CiteSpace-6.2R4, a widely used bibliometric analysis software package, was used for institutional analysis and reference burst analysis. VOSviewer 1.6.19 was used for journal co-citation analysis, author co-authorship and co-citation analysis. The ‘online platform for bibliometric analysis (https://bibliometric.com/app)’ was used to assess the total number of publications and the cooperation relationships between countries. Finally, we employed the bibliometric R software package (version R.4.3.1) in R-studio, for a comprehensive scientific analysis of the literature.
RESULTS
Our analysis included a total of 1466 publications, revealing a significant yearly increase in articles on the study of gastrointestinal tumor organoids. The United States (n = 393) and Helmholtz Association (n = 93) have emerged as the leading countries and institutions, respectively, in this field, with Hans Clevers and Toshiro Sato being the most contributing authors. The most influential journal in this field is Gastroenterology. The most impactful reference is "Long term expansion of epithelial organs from human colon, adenoma, adenocarcinoma, and Barrett's epithelium". Keywords analysis and citation burst analysis indicate that precision medicine, disease modeling, drug development and screening, and regenerative medicine are the most cutting-edge directions. These focal points were further detailed based on the literature.
CONCLUSION
This bibliometric study offers an objective and quantitative analysis of the research in this field, which can be considered as an important guide for next scientific research.
Core Tip: Bibliometrics was used to quantitatively analyze 1466 articles from Web of Science databases. Our manuscript provided a systematic and comprehensive analysis of the research trends and hotspots in this field, identified the most productive countries or regions, and highlighted the most influential journals, authors and references. We also offered a comprehensive and in-depth understanding of the research trends and hotspots in the field of gastrointestinal tumor organoids and discussed their future applications. This information will be beneficial for the future construction and application of gastrointestinal tumor organoids.
