Song YH, Li WL, Yang Z, Gao Y, Feng ZP. Loss of heterozygosity for chromosomes 16q in Wilms tumors predicts outcomes: A meta-analysis. World J Gastrointest Oncol 2024; 16(5): 2159-2167 [PMID: 38764827 DOI: 10.4251/wjgo.v16.i5.2159]
Corresponding Author of This Article
Zhi-Ping Feng, MS, Doctor, Department of Nuclear Medicine, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), No. 519 Kunzhou Road, Xishan District, Kunming 650118, Yunnan Province, China. fengzhiping@163.com
Research Domain of This Article
Cell Biology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. May 15, 2024; 16(5): 2159-2167 Published online May 15, 2024. doi: 10.4251/wjgo.v16.i5.2159
Loss of heterozygosity for chromosomes 16q in Wilms tumors predicts outcomes: A meta-analysis
Yuan-Hua Song, Wen-Ling Li, Zhen Yang, Yan Gao, Zhi-Ping Feng
Yuan-Hua Song, Wen-Ling Li, Zhen Yang, Yan Gao, Department of Oncology, Kunming Children's Hospital, Kunming 650103, Yunnan Province, China
Zhi-Ping Feng, Department of Nuclear Medicine, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), Kunming 650118, Yunnan Province, China
Author contributions: Feng ZP contributed to the conception of the study; Song YH, Li WL, Yang Z and Gao Y performed the experiment; Song YH, Li WL, Yang Z and Gao Y contributed significantly to analysis and manuscript preparation; Song YH performed the data analyses and wrote the manuscript.
Supported byYunnan Provincial Department of Science and Technology Provincial Basic Research Program (Kunming Medical Joint Special Project, No. 2019FE001 (-276); Kunming Health Science and Technology Talents Training Project and "Ten Hundred Thousands" Project Training Plan, No. 2020-SW (Backup)-121.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Ping Feng, MS, Doctor, Department of Nuclear Medicine, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital), No. 519 Kunzhou Road, Xishan District, Kunming 650118, Yunnan Province, China. fengzhiping@163.com
Received: November 15, 2023 Peer-review started: November 15, 2023 First decision: January 9, 2024 Revised: February 6, 2024 Accepted: March 12, 2024 Article in press: March 12, 2024 Published online: May 15, 2024 Processing time: 175 Days and 23.9 Hours
Abstract
BACKGROUND
The research findings suggest that the prognosis of children with Wilms tumor (WT) is affected by various factors. Some scholars have indicated that loss of heterozygosity (LOH) on chromosome 16q is associated with a poor prognosis in patients with WT.
AIM
To further elucidate this relationship, we conducted a meta-analysis.
METHODS
This meta-analysis was registered in INPLASY (INPLASY2023100060). We systematically searched databases including Embase, PubMed, Web of Science, Cochrane, and Google Scholar up to May 31, 2020, for randomized trials reporting any intrapartum fetal surveillance approach. The meta-analysis was performed within a frequentist framework, and the quality and network inconsistency of trials were assessed. Odds ratios and 95%CIs were calculated to report the relationship between event-free survival and 16q LOH in patients with WT.
RESULTS
Eleven cohort studies were included in this meta-analysis to estimate the relationship between event-free survival and 16q LOH in patients with WT (I2 = 25%, P < 0.001). As expected, 16q LOH can serve as an effective predictor of event-free survival in patients with WT (risk ratio = 1.95, 95%CI: 1.52–2.49, P < 0.001).
CONCLUSION
In pediatric patients with WT, there exists a partial correlation between 16q LOH and an unfavorable treatment prognosis. Clinical detection of 16q chromosome LOH warrants increased attention to the patient’s prognosis.
Core Tip: This study explores the prognostic significance of 16q loss of heterozygosity (LOH) in the treatment of patients with Wilms tumor (WT) in recent years. Utilizing a meta-analysis, the overall predictive value of 16q LOH in patients with WT is assessed. The findings indicate that 16q LOH is associated with a poor prognosis in patients with WT. Following clinical treatment, it is crucial to pay increased attention to patients’ prognostic value while adjusting their survival expectations.
