Cao F, Zhang HL, Guo C, Xu XL, Yuan Q. Targeting oxidative stress with natural products: A novel strategy for esophageal cancer therapy. World J Gastrointest Oncol 2024; 16(2): 287-299 [PMID: 38425393 DOI: 10.4251/wjgo.v16.i2.287]
Corresponding Author of This Article
Xue-Liang Xu, PhD, Doctor, Department of Rehabilitation III, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shierqiao Road, Chengdu 610072, Sichuan Province, China. 13408507171@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Feb 15, 2024; 16(2): 287-299 Published online Feb 15, 2024. doi: 10.4251/wjgo.v16.i2.287
Targeting oxidative stress with natural products: A novel strategy for esophageal cancer therapy
Fang Cao, Han-Ling Zhang, Cui Guo, Xue-Liang Xu, Qiang Yuan
Fang Cao, Xue-Liang Xu, Qiang Yuan, Department of Rehabilitation III, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China
Han-Ling Zhang, Department of Rehabilitation, Chongqing Fuling District Maternal and Child Health Hospital, Chongqing 408000, China
Cui Guo, Department of Rehabilitation, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China
Co-first authors: Fang Cao and Han-Ling Zhang.
Co-corresponding authors: Xue-Liang Xu and Qiang Yuan.
Author contributions: Cao F and Zhang HL jointly wrote the paper; Cao F and Guo C collected and reviewed the literature and made charts; Cao F and Zhang HL coordinated and jointly wrote and revised the paper; Xu XL and Yuan Q conceived the review and put forward core opinions and suggestions; Cao F and Zhang HL contributed equally substantial efforts throughout the entire research process. Because this study was conducted through collaboration, the entire research team included authors with various professional knowledge and skills from different fields. The designation of co-first authors accurately reflects the distribution of responsibilities and burdens related to the time and effort required to complete the research and synthesize the paper. Meanwhile, the designation of co-corresponding authors ensures the accuracy and professionalism of the article. All authors have read and approved the manuscript.
Conflict-of-interest statement: All authors declare no potential conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Liang Xu, PhD, Doctor, Department of Rehabilitation III, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shierqiao Road, Chengdu 610072, Sichuan Province, China. 13408507171@163.com
Received: October 9, 2023 Peer-review started: October 9, 2023 First decision: December 5, 2023 Revised: December 12, 2023 Accepted: January 12, 2024 Article in press: January 12, 2024 Published online: February 15, 2024 Processing time: 115 Days and 20.4 Hours
Abstract
Esophageal cancer (ESC) is a malignant tumor that originates from the mucosal epithelium of the esophagus and is part of the digestive tract. Although the exact pathogenesis of ESC has not been fully elucidated, excessive oxidative stress is an important characteristic that leads to the development of many cancers. Abnormal expression of several proteins and transcription factors contributes to oxidative stress in ESCs, which alters the growth and proliferation of ESCs and promotes their metastasis. Natural compounds, including alkaloids, terpenes, polyphenols, and xanthine compounds, can inhibit reactive oxygen species production in ESCs. These compounds reduce oxidative stress levels and subsequently inhibit the occurrence and progression of ESC through the regulation of targets and pathways such as the cytokine interleukins 6 and 10, superoxide dismutase, the NF-+ACY-kappa+ADs-B/MAPK pathway, and the mammalian Nrf2/ARE target pathway. Thus, targeting tumor oxidative stress has become a key focus in anti-ESC therapy. This review discusses the potential of Natural products (NPs) for treating ESCs and summarizes the application prospects of oxidative stress as a new target for ESC treatment. The findings of this review provide a reference for drug development targeting ESCs. Nonetheless, further high-quality studies will be necessary to determine the clinical efficacy of these various NPs.
Core Tip: This paper reviews the role of oxidative stress in esophageal cancer (ESC) development. Natural products (NPs) have shown beneficial effects throughout ESC disease processes. This review reveals the potential mechanisms by which NPs regulate ESC development through oxidative stress pathway.
