Shao ZB, He K, Su YB, Shi Z. Crosslink among cyclin-dependent kinase 9, ATP binding cassette transporter G2 and Beclin 1 in colorectal cancer. World J Gastrointest Oncol 2024; 16(12): 4778-4781 [PMID: 39678806 DOI: 10.4251/wjgo.v16.i12.4778]
Corresponding Author of This Article
Zhi Shi, MD, PhD, Professor, Department of Cell Biology & Institute of Biomedicine, Guangdong Provincial Biotechnology & Engineering Technology Research Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, Genomic Medicine Engineering Research Center of Ministry of Education, MOE Key Laboratory of Tumor Molecular Biology, National Engineering Research Center of Genetic Medicine, State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Life Science and Technology, Jinan University, No. 601 Huangpu Avenue West, Guangzhou 510632, Guangdong Province, China. tshizhi@jnu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Dec 15, 2024; 16(12): 4778-4781 Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4778
Crosslink among cyclin-dependent kinase 9, ATP binding cassette transporter G2 and Beclin 1 in colorectal cancer
Zhong-Bao Shao, Ke He, Yu-Bin Su, Zhi Shi
Zhong-Bao Shao, Ke He, Zhi Shi, Cancer Minimally Invasive Therapies Centre, Guangdong Second Provincial General Hospital, Jinan University, Guangzhou 510632, Guangdong Province, China
Zhong-Bao Shao, Yu-Bin Su, Zhi Shi, Department of Cell Biology & Institute of Biomedicine, Guangdong Provincial Biotechnology & Engineering Technology Research Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, Genomic Medicine Engineering Research Center of Ministry of Education, MOE Key Laboratory of Tumor Molecular Biology, National Engineering Research Center of Genetic Medicine, State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong Province, China
Co-first authors: Zhong-Bao Shao and Ke He.
Author contributions: Shao ZB, He K, Su YB, and Shi Z contributed to this paper; Shi Z designed the overall concept and outline of the manuscript; Su YB contributed to the discussion of the manuscript; Shao ZB and He K contributed to the writing, and editing the manuscript, and review of literature, they are the co-first authors of this article.
Supported bythe National Natural Science Foundation of China, No. 82272996; and the Science and Technology Program of Guangzhou, No. 202206010081.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi Shi, MD, PhD, Professor, Department of Cell Biology & Institute of Biomedicine, Guangdong Provincial Biotechnology & Engineering Technology Research Center, Guangdong Provincial Key Laboratory of Bioengineering Medicine, Genomic Medicine Engineering Research Center of Ministry of Education, MOE Key Laboratory of Tumor Molecular Biology, National Engineering Research Center of Genetic Medicine, State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Life Science and Technology, Jinan University, No. 601 Huangpu Avenue West, Guangzhou 510632, Guangdong Province, China. tshizhi@jnu.edu.cn
Received: August 21, 2024 Revised: September 19, 2024 Accepted: October 12, 2024 Published online: December 15, 2024 Processing time: 83 Days and 0.9 Hours
Abstract
Colorectal cancer (CRC) ranks third in the number of cancers mainly because of the inability to diagnose it at an early stage. The pathogenesis of CRC is complicated, which is the result of the complex interaction of multiple genetic and environmental factors. Currently, one of the main treatments for CRC is chemotherapy. But the primary cause of CRC treatment failure is drug resistance. The expression of cyclin-dependent kinase 9 (CDK9) was correlated with elevated autophagy levels in colon cancer, and high expression of CDK9 indicates a poor prognosis in CRC. The incidence of autophagy and the expressions of Beclin 1 and ATP binding cassette transporter G2 are different in left and right colon cancer, and autophagy may be involved in the occurrence of chemotherapy resistance. In this article, the roles of CDK9, ATP binding cassette transporter G2 and Beclin 1 in CRC were elucidated, emphasizing the linkages among them and providing potential therapeutic targets of CRC.
Core Tip: The expression of cyclin-dependent kinase 9 (CDK9) was correlated with elevated autophagy levels in colon cancer, and high expression of CDK9 indicates a poor prognosis in colorectal cancer (CRC). The incidence of autophagy and the expressions of Beclin 1 and ATP binding cassette transporter G2 were different between left and right colon cancer. The roles of CDK9, ATP binding cassette transporter G2 and Beclin 1 in CRC were clarified, underlining the linkages among them and providing potential therapeutic targets of CRC.
