Sforzin I, Borad M, Uson Junior PLS. Are preoperative inflammatory and nutritional markers important for the prognosis of patients with peritoneal metastasis of colorectal cancer? World J Gastrointest Oncol 2024; 16(11): 4522-4527 [PMID: 39554733 DOI: 10.4251/wjgo.v16.i11.4522]
Corresponding Author of This Article
Pedro Luiz Serrano Uson Junior, MD, Academic Editor, Academic Research, Assistant Professor, Teacher, Center for Personalized Medicine, Hospital Israelita Albert Einstein, Avenida Albert Einstein 627, São Paulo 05652900, Brazil. pedro.serrano@einstein.br
Research Domain of This Article
Oncology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Nov 15, 2024; 16(11): 4522-4527 Published online Nov 15, 2024. doi: 10.4251/wjgo.v16.i11.4522
Are preoperative inflammatory and nutritional markers important for the prognosis of patients with peritoneal metastasis of colorectal cancer?
Isabella Sforzin, Mitesh Borad, Pedro Luiz Serrano Uson Junior
Isabella Sforzin, Pedro Luiz Serrano Uson Junior, Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo 05652900, Brazil
Mitesh Borad, Division of Hematology-Oncology, Department of Medicine, Mayo Clinic Arizona, Mayo Clinic Cancer Center, Phoenix, AZ 85054, United States
Author contributions: Uson Junior PLS, Borad M, and Sforzin I contributed to the development of this paper, including the writing, editing of the manuscript, preparation of tables, and review of the literature.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pedro Luiz Serrano Uson Junior, MD, Academic Editor, Academic Research, Assistant Professor, Teacher, Center for Personalized Medicine, Hospital Israelita Albert Einstein, Avenida Albert Einstein 627, São Paulo 05652900, Brazil. pedro.serrano@einstein.br
Received: August 1, 2024 Revised: September 14, 2024 Accepted: September 24, 2024 Published online: November 15, 2024 Processing time: 84 Days and 14.5 Hours
Abstract
Colorectal cancer (CRC) is a type of cancer that grows from polypoid lesions developing over the years. It has a high incidence of about 1.8 million new cases annually. While screening and lifestyle modifications have stabilized the rate of CRC in high-income countries, the incidence of early-onset CRC is increasing globally. The worst prognosis for this cancer is linked to recurrence and metastasis, with peritoneal metastasis occurring in 8% to 20% of cases. In these cases, treatment with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is indicated. However, this approach is risky and requires careful selection of patients who will truly benefit from it. This article will discuss the correlation between nutrition and inflammation in patients with peritoneal metastasis and advanced CRC, emphasizing the importance of nutritional and inflammatory markers for assessing disease status. Finally, we will highlight the main biomarkers in the field.
Core Tip: In this study, the clinical data of patients with colorectal cancer (CRC) from a single center were retrospectively analyzed. A high neutrophil-to-lymphocyte ratio and low hemoglobin levels were independent predictive risk factors for poor prognosis in patients with peritoneal metastasis (PM) of CRC. The established nomogram including CA 19-9 levels and patient age accurately predicted the overall survival of patients having PM, indicating its usefulness as a valuable prognostic tool for this patient cohort.
