Li JY, Gao XZ, Zhang J, Meng XZ, Cao YX, Zhao K. Comprehensive evaluation of rare case: From diagnosis to treatment of a sigmoid Schwannoma: A case report. World J Gastrointest Oncol 2024; 16(1): 244-250 [PMID: 38292849 DOI: 10.4251/wjgo.v16.i1.244]
Corresponding Author of This Article
Jian Zhang, MD, Chief Doctor, Department of Gastroenterology, The First People's Hospital of Jining, No. 269 Mengzi Avenue, Jining Hi-Tech Zone, Jining 272000, Shandong Province, China. rmyyzj88@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jing-Yi Li, Xi-Zhuang Gao, Xiang-Zheng Meng, Kun Zhao, Clinical Medical College of Jining Medical University, Jining Medical University, Jining 272000, Shandong Province, China
Jian Zhang, Yi-Xian Cao, Department of Gastroenterology, The First People's Hospital of Jining, Jining 272000, Shandong Province, China
Author contributions: Li JY wrote the manuscript and designed the study; Gao XZ and Zhang J supervised the study; Zhao K, Meng XZ, and Cao YX participated in the investigation and revision; All the authors read and approved the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian Zhang, MD, Chief Doctor, Department of Gastroenterology, The First People's Hospital of Jining, No. 269 Mengzi Avenue, Jining Hi-Tech Zone, Jining 272000, Shandong Province, China. rmyyzj88@126.com
Received: November 4, 2023 Peer-review started: November 4, 2023 First decision: November 22, 2023 Revised: December 6, 2023 Accepted: December 18, 2023 Article in press: December 18, 2023 Published online: January 15, 2024 Processing time: 67 Days and 17.1 Hours
Abstract
BACKGROUND
Schwannomas are uncommon tumors originating from Schwann cells, forming the neural sheath. They account for approximately 2%-6% of all mesenchymal tumors and are most commonly identified in peripheral nerve trunks, with rarity in the gastrointestinal tract. Among gastrointestinal locations, the stomach harbors the majority of nerve sheath tumors, while such occurrences in the sigmoid colon are exceptionally infrequent.
CASE SUMMARY
This study presented a clinical case involving a 60-year-old female patient who, during colonoscopy, was diagnosed with a submucosal lesion that was later identified as a nerve sheath tumor. The patient underwent surgical resection, and the diagnosis was confirmed through immunohistochemistry. This study highlighted an exceptionally uncommon occurrence of a nerve sheath tumor in the sigmoid colon, which was effectively managed within our department. Additionally, a comprehensive review of relevant studies was conducted.
CONCLUSION
The preoperative diagnosis of nerve sheath tumors poses challenges, as the definitive diagnosis still relies on pathology and immunohistochemistry. Although categorized as benign, these tumors have the potential to demonstrate malignant behavior. Consequently, the optimal treatment approach entails the complete surgical excision of the tumor, ensuring the absence of residual lesions at the margins.
Core Tip: This study describes an uncommon nerve sheath tumor occurrence in the sigmoid colon, which was initially identified as a submucosal lesion and subsequently verified through histopathological and immunohistochemical analyses. The findings suggest that immunohistochemistry is the preferred diagnostic approach for this condition, and endoscopic surgery stands out as the optimal treatment modality.
