Zeng XY, Qiu XZ, Wu JN, Liang SM, Huang JA, Liu SQ. Interaction mechanisms between autophagy and ferroptosis: Potential role in colorectal cancer. World J Gastrointest Oncol 2023; 15(7): 1135-1148 [PMID: 37546557 DOI: 10.4251/wjgo.v15.i7.1135]
Corresponding Author of This Article
Shi-Quan Liu, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning 530000, Guangxi Zhuang Autonomous Region, China. poempower@163.com
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xin-Ya Zeng, Xin-Ze Qiu, Sheng-Mei Liang, Jie-An Huang, Shi-Quan Liu, Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi Zhuang Autonomous Region, China
Jiang-Ni Wu, Department of Pathology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi Zhuang Autonomous Region, China
Author contributions: Zeng XY and Liu SQ designed the article framework; Zeng XY drafted the manuscript; Qiu XZ, Wu JN, Liang SM and Huang JA contributed to critical revision and supervised the manuscript; all authors have read and approved the final manuscript.
Supported bythe National Natural Science Foundation of China, No. 82260579; the Natural Science Foundation of Guangxi, China, No. 2020GXNSFAA159056; and the Natural Science Foundation Fostering Science Foundation of the Second Affiliated Hospital of Guangxi Medical University, Guangxi, China, No. GJPY2018010.
Conflict-of-interest statement: The authors declare no conflicts of interest related to this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shi-Quan Liu, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, Nanning 530000, Guangxi Zhuang Autonomous Region, China. poempower@163.com
Received: February 3, 2023 Peer-review started: February 3, 2023 First decision: March 14, 2023 Revised: March 28, 2023 Accepted: April 23, 2023 Article in press: April 23, 2023 Published online: July 15, 2023 Processing time: 158 Days and 21.1 Hours
Abstract
Colorectal cancer (CRC) is a common malignancy that has the second highest incidence and mortality rate. Although there are many personalized treatment options for CRC, the therapeutic effects are ultimately limited by drug resistance. Studies have aimed to block the initiation and progression of CRC by inducing cell death to overcome this obstacle. Substantial evidence has indicated that both autophagy and ferroptosis play important regulatory roles in CRC. Autophagy, a lysosome-dependent process by which cellular proteins and organelles are degraded, is the basic mechanism for maintaining cell homeostasis. The duality and complexity of autophagy in cancer therapy is a hot topic of discussion. Ferroptosis, a regulated cell death pathway, is associated with iron accumulation-induced lipid peroxidation. The activation of ferroptosis can suppress CRC proliferation, invasion and drug resistance. Furthermore, recent studies have suggested an interaction between autophagy and ferroptosis. Autophagy can selectively degrade certain cellular contents to provide raw materials for ferroptosis, ultimately achieving antitumor and anti-drug resistance. Therefore, exploring the interaction between autophagy and ferroptosis could reveal novel ideas for the treatment of CRC. In this review, we describe the mechanisms of autophagy and ferroptosis, focusing on their roles in CRC and the crosstalk between them.
Core Tip: Ferroptosis is a mode of cell death centered on iron accumulation and lipid peroxidation that plays a crucial role in colorectal cancer (CRC). Recently, an increasing number of studies have found that autophagy and ferroptosis have a cross-talk relationship in CRC. Enhancing the antitumor effect through autophagy-dependent ferroptosis will become a hot topic in medical biology. This review describes the mechanisms of autophagy and ferroptosis and their interactions in CRC with a goal of providing new strategies for the treatment of CRC.
