Pérez Lara FJ, Hebrero Jimenez ML, Moya Donoso FJ, Hernández Gonzalez JM, Pitarch Martinez M, Prieto-Puga Arjona T. Review of incomplete macroscopic resections (R2) in rectal cancer: Treatment, prognosis and future perspectives. World J Gastrointest Oncol 2021; 13(9): 1062-1072 [PMID: 34616512 DOI: 10.4251/wjgo.v13.i9.1062]
Corresponding Author of This Article
Francisco Javier Pérez Lara, PhD, Doctor, Surgeon, Department of Surgery, Antequera Hospital, Avda Poeta Muñoz Rojas sn, Málaga 29200, Spain. javinewyork@hotmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Sep 15, 2021; 13(9): 1062-1072 Published online Sep 15, 2021. doi: 10.4251/wjgo.v13.i9.1062
Review of incomplete macroscopic resections (R2) in rectal cancer: Treatment, prognosis and future perspectives
Francisco Javier Pérez Lara, Maria Luisa Hebrero Jimenez, Francisco Javier Moya Donoso, Jose Manuel Hernández Gonzalez, Maria Pitarch Martinez, Tatiana Prieto-Puga Arjona
Francisco Javier Pérez Lara, Francisco Javier Moya Donoso, Jose Manuel Hernández Gonzalez, Maria Pitarch Martinez, Tatiana Prieto-Puga Arjona, Department of Surgery, Antequera Hospital, Málaga 29200, Spain
Maria Luisa Hebrero Jimenez, Department of Oncologic Radiotherapy, Hopital Regional de Málaga, Málaga 29010, Spain
Author contributions: Pérez Lara FJ made a substantial contribution to the concept and design, drafted the article or revised it critically for important intellectual content and approved the version to be published; Hebrero Jimenez ML drafted the article or revised it critically for important intellectual content and approved the version to be published; Moya Donoso F approved the version to be published; Hernández González JM approved the version to be published; Pitarch Martínez M approved the version to be published; Prieto-Puga T approved the version to be published.
Conflict-of-interest statement: No conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Francisco Javier Pérez Lara, PhD, Doctor, Surgeon, Department of Surgery, Antequera Hospital, Avda Poeta Muñoz Rojas sn, Málaga 29200, Spain. javinewyork@hotmail.com
Received: February 9, 2021 Peer-review started: February 9, 2021 First decision: April 19, 2021 Revised: April 28, 2021 Accepted: July 23, 2021 Article in press: July 23, 2021 Published online: September 15, 2021
Abstract
Colorectal cancer is one of the most prevalent tumours, but with improved treatment and early detection, its prognosis has greatly improved in recent years. However, when the tumour is locally advanced at diagnosis or if there is local recurrence, it is more difficult to perform a complete tumour resection, and there may be a residual macroscopic tumour. In this paper, we review the literature on residual macroscopic tumour resections, concerning both locally advanced primary tumours and recurrences, evaluating the main problems encountered, the treatments applied, the prognosis and future perspectives in this field.
Core Tip: We review various series of rectal cancer with incomplete macroscopic resection, commenting on the problems addressed, the approaches taken, the oncological results obtained and future perspectives.
