Duan F, Bai YH, Cui L, Li XH, Yan JY, Wang MQ. Simultaneous transarterial chemoembolization and radiofrequency ablation for large hepatocellular carcinoma. World J Gastrointest Oncol 2020; 12(1): 92-100 [PMID: 31966917 DOI: 10.4251/wjgo.v12.i1.92]
Corresponding Author of This Article
Mao-Qiang Wang, MD, PhD, Professor, Department of Interventional Radiology, General Hospital of Chinese People’s Liberation Army, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. wangmq@vip.sina.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jan 15, 2020; 12(1): 92-100 Published online Jan 15, 2020. doi: 10.4251/wjgo.v12.i1.92
Simultaneous transarterial chemoembolization and radiofrequency ablation for large hepatocellular carcinoma
Feng Duan, Yan-Hua Bai, Li Cui, Xiao-Hui Li, Jie-Yu Yan, Mao-Qiang Wang
Feng Duan, Yan-Hua Bai, Li Cui, Xiao-Hui Li, Jie-Yu Yan, Mao-Qiang Wang, Department of Interventional Radiology, General Hospital of Chinese People’s Liberation Army, Beijing 100853, China
Author contributions: Duan F and Wang MQ designed research; Duan F, Li XH, Yan JY, Wang MQ performed clinical research; Bai YH and Cui L analyzed data; Duan F and Cui L wrote the paper, all authors read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the General Hospital of People’s Liberation Army Institutional Review Board.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest related to this article.
Data sharing statement: No additional unpublished data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mao-Qiang Wang, MD, PhD, Professor, Department of Interventional Radiology, General Hospital of Chinese People’s Liberation Army, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. wangmq@vip.sina.com
Received: September 5, 2019 Peer-review started: September 5, 2019 First decision: October 18, 2019 Revised: October 25, 2019 Accepted: December 6, 2019 Article in press: December 6, 2019 Published online: January 15, 2020 Processing time: 117 Days and 6.7 Hours
Abstract
BACKGROUND
Hepatocellular carcinoma (HCC) is a common cancer and a leading cause of tumor-related death. Patients with large HCC (≥ 8 cm) are at an advanced stage and have poor prognosis, and hepatic resection may not be suitable, and the incidence of postoperative recurrence is high.
AIM
To evaluate recurrence and mid-term survival of patients with large HCC treated by transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA).
METHODS
This was a retrospective study. From 2010 to 2013, 46 consecutive patients with large HCC were treated with simultaneous TACE and RFA. Thirty-five of 46 patients had a single tumor. Progression-free survival (PFS) and overall survival (OS) were analyzed at 2 years and 3 years, respectively.
RESULTS
Forty-six patients treated by simultaneous TACE and RFA had no significant complications and treatment was successful. After 3 years, median PFS and OS were 10.21 ± 1.58 mo and 26.44 ± 2.26 mo, retrospectively. The survival rate was 67.5% after 2 years and 55.67% after 3 years.
CONCLUSION
These preliminary data show that simultaneous TACE and RFA are safe and effective for large HCC.
Core tip: Hepatocellular carcinoma (HCC) is a common cancer and a leading cause of tumor-related death. Patients who have large HCC (≥ 8 cm) are at advanced stages and have poor prognosis. Interventional treatment including transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) are commonly used for HCC. However, for patients with large HCC, the use of TACE alone and RFA alone can only lead to partial tumor necrosis with poor local control. Our study showed that simultaneous combination of TACE and RFA may improve therapeutic efficacy and survival for patients with large HCC.
