Comparison between colorectal low- and high-grade mucinous adenocarcinoma with MUC1 and MUC5AC

doi:10.4251/wjgo.v1.i1.69

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Oct 15, 2009 (publication date) through Jul 30, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Oct 15, 2009; 1(1): 69-73
Published online Oct 15, 2009. doi: 10.4251/wjgo.v1.i1.69

Comparison between colorectal low- and high-grade mucinous adenocarcinoma with MUC1 and MUC5AC

Masayuki Onodera, Takashi Nishigami, Ikuko Torii, Ayuko Sato, Li-Hua Tao, Tatsuki R Kataoka, Reigetsu Yoshikawa, Tohru Tsujimura

Masayuki Onodera, Takashi Nishigami, Ikuko Torii, Ayuko Sato, Li-Hua Tao, Tatsuki R Kataoka, Tohru Tsujimura, Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan

Reigetsu Yoshikawa, Department of Surgery, Hyogo College of Medicine, Nishinomiya, 663-8501, Japan

Author contributions: Onodera M, Yoshikawa R and Nishigami T collected materials and immunohistochemical analysis; Torii I, Sato A, and Tao LH cooperated in immunohistochemical staining; Kataoka TR analyzed the data statistically; Tsujimura T designed this study.

Supported by Grants-Aid for Researchers, Hyogo College of Medicine and Grants-in Aid for Scientific Research and Hitec Research Center Grant from the Ministry of Education, Science, Sports, Culture, and Technology of Japan

Correspondence to: Tohru Tsujimura, MD, PhD, Department of Pathology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. tohru@hyo-med.ac.jp

Telephone: +81-798-456425 Fax: +81-798-456426

Received: March 23, 2009
Revised: July 31, 2009
Accepted: August 7, 2009
Published online: October 15, 2009

Abstract

AIM: To explore useful prognostic factors for mucinous adenocarcinoma (MAC) in the colon and rectum.

METHODS: MAC was divided into low- and high-grade types based on the degree of structural differentiation; low-grade MAC arisen from well to moderately differentiated adenocarcinoma and papillary carcinoma, and high-grade MAC from poorly differentiated adenocarcinoma and signet ring cell carcinoma. Immunohistochemically, the expression of 2 types of MUC1 (MUC1/DF and MUC1/CORE), MUC2, 2 types of MUC5AC (MUC5AC/CHL2 and HGM), MUC6, CDX2, and CD10 was examined in 16 cases of MAC consisting of 6 low- and 10 high-grade types.

RESULTS: MUC1/DF3 was expressed in 3 of 6 low-grade MAC (50%) and 10 of 10 high-grade MAC (100%). MUC1/CORE was expressed in 1 of 6 low-grade MAC (16.7%) and 7 of 10 high-grade MAC (70%). MUC2 was expressed in all MAC regardless of the grade. MUC5AC was expressed in 6 of 6 low-grade MAC (100%) and 4 of 10 high-grade MAC (40%). HGM was expressed in 5 of 6 low-grade MAC (83.3%) and 6 of 10 high-grade MAC (60%). Expression of MUC6 and CD10 was undetected in all MAC regardless of the grade. CDX2 was expressed in 5 of 6 low-grade MAC (83.3%) and 7 of 10 high-grade MAC (70%). Taken together, MUC1/DF3 was expressed significantly more frequently in high-grade MAC than in low-grade, and MUC5AC/CHL2 was expressed significantly more frequently in low-grade MAC than in high-grade.

CONCLUSION: It is proposed that MUC1/DF3 and MUC5AC/CHL2 immunostaining is useful to discriminate high-grade MAC from low-grade MAC.

Keywords: Mucinous adenocarcinoma, Colon, Rectum, MUC1, MUC5AC