Assessment of disease activity in inflammatory bowel diseases: Non-invasive biomarkers and endoscopic scores

Table 1 Diagnostic accuracy of fecal calprotectin in inflammatory bowel diseases

Ref.	Patients number	Calprotectin cut-off (μg/g)	Sensitivity (%)	Specificity (%)	Correlation with clinical, endoscopic and/or histological data
Kennedy et al[98], 2019	918	115	N/A	N/A	disease location
Monteiro et al[99], 2018	75	100	78, 6	87	SBEC-Lewis score
Pendsé et al[100], 2017	69	120	83	52	MRI, DWI, MEGS
Kopylov et al[101], 2016	463	50	83	53	endoscopic capsule
Chung-Faye et al[102], 2014	109	250	90	82	histology score
Fascì-Spurio et al[103], 2014	114	110	76	70	SBMRI
Makanyanga et al[43], 2014	71	100	70	63	MEGS, CDAI
Lobatón et al[104], 2013	115	272	79	97	CDEIS
D'Haens et al[65], 2012	87	250	60	79	CDEIS e SES-CD
Koulaouzidis et al[105], 2011	67	100	66	78	SBEC
Jensen et al[106], 2011	83	50	95	56	Ileo-colonoscopy, SBEC and surgery
Schoepfer et al[54], 2010	140	70	87	72	SES-CD, CDAI
Vieira et al[66], 2009	78	200	88,6	97,1	CDAI, MDAI
Xiang et al[64], 2008	66	50	79,4	91,9	DAI (Sutherland criteria)
Sipponen et al[107], 2008	77	200	70	92	CDEIS

SBEC: Small bowel enteroclysis; MRI: Magnetic resonance imaging; DWI: Diffusion-weighted imaging; MEGS: Global magnetic resonance enterography score; SBMRI: Small bowel magnetic resonance imaging; CDAI: Crohn’s disease activity index; CDEIS: Crohn's disease endoscopic activity index of severity; SES-CD: Simple endoscopic score for Crohn's disease; MDAI: Mayo disease activity index; DAI: Disease activity index.