Review
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Dec 16, 2020; 12(12): 504-520
Published online Dec 16, 2020. doi: 10.4253/wjge.v12.i12.504
Assessment of disease activity in inflammatory bowel diseases: Non-invasive biomarkers and endoscopic scores
Bruno Lima Rodrigues, Márcia Carolina Mazzaro, Cristiane Kibune Nagasako, Maria de Lourdes Setsuko Ayrizono, João José Fagundes, Raquel Franco Leal
Bruno Lima Rodrigues, Márcia Carolina Mazzaro, Maria de Lourdes Setsuko Ayrizono, João José Fagundes, Raquel Franco Leal, Inflammatory Bowel Disease Research Laboratory, Gastrocenter, Colorectal Surgery Unit, Department of Surgery, School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-878, São Paulo, Brazil
Cristiane Kibune Nagasako, Department of Gastroenterology, Gastrocenter, School of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-878, São Paulo, Brazil
Author contributions: All authors wrote this manuscript and contributed to its final revision.
Supported by National Council for Scientific and Technological Development (CNPq), No. 301388/2018-0; Funding for Education, Research and Extension Support (FAEPEX), University of Campinas.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Raquel Franco Leal, MD, PhD, Associate Professor, Research Scientist, Inflammatory Bowel Disease Research Laboratory, Gastrocenter, Colorectal Surgery Unit, Department of Surgery, School of Medical Sciences, University of Campinas (UNICAMP), Carlos Chagas Street, 420, Cidade Universitária Zeferino Vaz, Campinas 13083-878, São Paulo, Brazil. rafranco.unicamp@gmail.com
Received: July 1, 2020
Peer-review started: July 1, 2020
First decision: September 21, 2020
Revised: October 6, 2020
Accepted: November 5, 2020
Article in press: November 5, 2020
Published online: December 16, 2020
Core Tip

Core Tip: Biomarkers are relevant for diagnostic support, differentiation between Crohn’s disease and ulcerative colitis, determination of disease activity, and in prediction of response to therapy. This review discusses the most recent studies that correlate non-invasive clinical biomarkers of disease activity with the endoscopic scores available in clinical practice.