Nonaka K, Arai S, Ishikawa K, Nakao M, Nakai Y, Togawa O, Nagata K, Shimizu M, Sasaki Y, Kita H. Short term results of endoscopic submucosal dissection in superficial esophageal squamous cell neoplasms. World J Gastrointest Endosc 2010; 2(2): 69-74 [PMID: 21160693 DOI: 10.4253/wjge.v2.i2.69]
Corresponding Author of This Article
Hiroto Kita, MD, Department of Gastroenterology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan. hkita@saitama-med.ac.jp
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World J Gastrointest Endosc. Feb 16, 2010; 2(2): 69-74 Published online Feb 16, 2010. doi: 10.4253/wjge.v2.i2.69
Short term results of endoscopic submucosal dissection in superficial esophageal squamous cell neoplasms
Kouichi Nonaka, Shin Arai, Keiko Ishikawa, Masamitsu Nakao, Yousuke Nakai, Osamu Togawa, Koji Nagata, Michio Shimizu, Yutaka Sasaki, Hiroto Kita
Kouichi Nonaka, Shin Arai, Keiko Ishikawa, Masamitsu Nakao, Yousuke Nakai, Osamu Togawa, Hiroto Kita, Department of Gastroenterology, Saitama Medical University International Medical Center, Saitama 350-1298, Japan
Koji Nagata, Michio Shimizu, Department of Pathology, Saitama Medical University International Medical Center, Saitama 350-1298, Japan
Yutaka Sasaki, Department of Gastroenterology, Faculty of Medicine, Kumamoto University, Kumamoto 860-0856, Japan
Author contributions: Nonaka K: study design, analysis and interpretation of data, drafting of the article; Arai S, Ishikawa K: critical revision of the article for important intellectual content; Nakao M, Nakai Y, Togawa O, Sasaki Y: analysis and interpretation of the data; Nagata K, Shimizu M: pathological analysis; Hiroto K: final approval of the article.
Correspondence to: Hiroto Kita, MD, Department of Gastroenterology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan. hkita@saitama-med.ac.jp
Telephone: +81-4-29844111 Fax: +81-4-29844741
Received: June 12, 2009 Revised: January 12, 2010 Accepted: January 19, 2010 Published online: February 16, 2010
Abstract
AIM: To evaluate the efficacy of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms.
METHODS: Between July 2007 and March 2009, 27 consecutive superficial esophageal squamous cell neoplasms in 25 enrolled patients were treated by endoscopic submucosal dissection. The therapeutic efficacy, complications, and follow-up results were assessed.
RESULTS: The mean size of the lesions was 21 ± 13 mm (range 2-55 mm); the mean size of the resection specimens was 32 ± 12 mm (range 10-70 mm). The en block resection rate was 100% (27/27), and en block resection with tumor-free lateral/basal margins was 88.9% (24/27). Perforation occurred in 1 patient who was managed by conservative medical treatments. None of the patients developed local recurrence or distant metastasis in the follow-up period.
CONCLUSION: Endoscopic submucosal dissection is applicable to superficial esophageal squamous cell neoplasms with promising results.
