Han SY, Papachristou GI, Shah RJ, Conwell DL. Effect of pancreatic endotherapy on quality of life in chronic pancreatitis patients: A systematic review. World J Gastrointest Endosc 2021; 13(8): 336-344 [PMID: 34512881 DOI: 10.4253/wjge.v13.i8.336]
Corresponding Author of This Article
Samuel Y Han, MD, MS, Assistant Professor, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W 12th Ave. 2nd Floor Doan Office Tower, Columbus, OH 43210, United States. samuel.han@osumc.edu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Endosc. Aug 16, 2021; 13(8): 336-344 Published online Aug 16, 2021. doi: 10.4253/wjge.v13.i8.336
Effect of pancreatic endotherapy on quality of life in chronic pancreatitis patients: A systematic review
Samuel Y Han, Georgios I Papachristou, Raj J Shah, Darwin L Conwell
Samuel Y Han, Georgios I Papachristou, Darwin L Conwell, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States
Raj J Shah, Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States
Author contributions: Han SY and Conwell DL wrote the paper; Papachristou GI and Shah RJ reviewed and revised the paper.
Conflict-of-interest statement: Papachristou GI is a Consultant for Olympus, and has received research funding from AbbVie; Author Shah RJ is an Advisory Board Member and Consultant for Boston Scientific and Consultant for Olympus and Cook Endoscopy; Conwell DC received support from the National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under award number U01 DK108327.
PRISMA 2009 Checklist statement: This manuscript was presented in accordance with the PRISMA guidelines for a systematic review.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Samuel Y Han, MD, MS, Assistant Professor, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, 395 W 12th Ave. 2nd Floor Doan Office Tower, Columbus, OH 43210, United States. samuel.han@osumc.edu
Received: February 12, 2021 Peer-review started: February 12, 2021 First decision: May 5, 2021 Revised: June 11, 2021 Accepted: July 13, 2021 Article in press: July 13, 2021 Published online: August 16, 2021 Processing time: 180 Days and 14.5 Hours
Abstract
BACKGROUND
Pancreatic endotherapy provides treatment options for the management of chronic pancreatitis-related structural complications such as pancreatic duct stones, strictures, and pancreatic fluid collections. Most studies detailing endotherapy, however, have focused on technical success outcomes such as stone clearance or stricture resolution.
AIM
To review the effect of pancreatic endotherapy on patient-centered outcomes.
METHODS
Systematic review of studies examining pancreatic endotherapy.
RESULTS
A total of 13 studies including 3 randomized clinical trials were included. The majority of studies found an improvement in quality of life with pancreatic endotherapy.
CONCLUSION
While pancreatic endotherapy does appear to improve quality of life, there are clear gaps in knowledge regarding many pancreatic endotherapy modalities. Furthermore, qualitative analysis is lacking in these studies and further work is needed to elucidate the patient experience with pancreatic endotherapy.
Core Tip: Chronic pancreatitis remains difficult to treat and pancreatic endotherapy offers one option for the management of chronic pancreatitis-related complications. Pancreatic duct decompression via pancreatic duct stone lithotripsy and stenting appears to improve the quality of life of these patients in the short-term. More studies, however, are needed to examine the effect of endotherapy modalities such as endoscopic transmural drainage of pancreatic fluid collections, celiac plexus blocks and more recent innovations on quality of life in these patients.
