Clinicopathological features of 11 cases of chronic hepatitis B infection complicated with primary biliary cholangitis

Table 1 Clinical characteristics of 11 cases of chronic hepatitis B complicated with primary biliary cholangitis

No.	Sex	Age	TBIL	ALT	AST	ALP	GGT	TBA	Albumin (g/L)	AMA-M2	gp120	sp100	ANA	IgM	IgG	HBV DNA (Log)	Platelet (1 × 109/L)	Fatigue	Pruritus
1	Woman	42	22.2	87	56	47	67	17	32.2	++	+	-	+	4.25	21.15	7.21	9.21	+	+
2	Man	60	45.2	224	175	154	116	30	36.5	+	-	-	-	1.25	11.23	4.25	12.66	-	-
3	Woman	52	13.5	35	24	57	57	12	41.2	+	-	-	-	1.65	9.32	4.68	8.35	-	-
4	Man	37	15.5	22	16	46	47	8	38.2	+	-	-	-	1.42	8.65	5.32	16.35	-	-
5	Man	39	16.0	35	24	65	37	12	37.9	+	-	-	-	1.87	10.32	-	15.32	-	-
6	Woman	37	16.3	27	18	74	58	14	36.4	++	-	-	-	2.01	11.56	6.14	11.25	-	-
7	Man	57	422.4	243	215	767	837	147	32.2	+	-	-	-	4.36	24.32	4.35	13.65	+	+
8	Woman	52	20.4	156	87	167	224	25	40.2	++	+	-	+	0.98	10.48	3.57	14.25	+	-
9	Woman	32	11.3	25	11	37	26	37	41.6	+	-	-	-	1.14	9.65	4.25	24.22	-	-
10	Woman	28	32.7	18	15	166	89	18	39.2	-	-	-	-	1.58	13.64	-	21.03	-	-
11	Woman	51	25.6	87	26	185	98	9	38.1	-	-	-	-	1.67	10.35	-	18.21	-	-

TBIL: Total bilirubin; TBA: Total bile acid; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: γ-glutamyltransferase; ALP: Alkaline phosphatase; AMA-M2: Antimitochondrial antibody and subtypes-M2; ANA: Antibodies against gp210, antibodies against sp100, antinuclear antibodies; Ig: Immunoglobulin.

Table 2 Changes of biochemical indexes before and after treatment

	TBIL	ALT	AST	ALP	GGT	TBA	IgM	IgG
Before treatment	20.4 (11.3-422.4)	35 (18-243)	24 (11-215)	66 (37-767)	58 (17-837)	17 (8-147)	1.65 (0.98-4.37)	12.7 (8.6-24.3)
After treatment	17.7 (6.7-21.2)	27 (12-63)	21 (15-43)	47 (38-107)	25 (16-42)	9 (6-20)	1.4 (1.1-2.5)	11.3 (6.8-15.3)
Statistical value	1.223	2.351	1.656	1.326	2.369	1.632	2.435	0.931
P value	0.248	0.041	0.129	0.214	0.039	0.134	0.031	0.374

TBIL: Total bilirubin; TBA: Total bile acid; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: γ-glutamyltransferase; ALP: Alkaline phosphatase; Ig: Immunoglobulin.

Table 3 Pathological characteristics of 11 cases of chronic hepatitis B complicated with primary biliary cholangitis

No.	II	BN	LI	DI	FDL	BIH	DU	HBsAg staining	HBcAg staining	METAVIR activity score	METAVIR stage	Ludwig stage
1	1	-	2	+	+	-	-	+	+	2	F1	I
2	1	-	1	+	-	-	-	-	-	1	F1	II
3	0	-	1	+	+	-	-	+	-	1	F1	I
4	2	+	2	+	-	+	-	-	+	2	F1	II
5	0	-	1	+	+	-	-	+	-	1	F2	I
6	1	-	1	+	-	+	-	+	-	1	F1	I
7	3	+	2	+	+	+	-	+	+	3	F3	II
8	2	+	1	+	-	+	-	-	-	2	F1	I
9	1	-	1	+	-	+	+	+	-	1	F4	III
10	0	-	0	+	+	-	-	-	-	0	F0	I
11	1	-	1	+	-	-	-	+	-	1	F0	I

II: Interfacial inflammation; BN: Bridging necrosis; LI: Lobular inflammation; DI: Ductal injure; FDL: Florid duct lesion; BIH: Biliary interface hepatitis; DU: Ductopenia; HBsAg: Hepatitis B surface antigen; HBcAg: Hepatitis B core antigen.