Observational Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Apr 27, 2023; 15(4): 577-584
Published online Apr 27, 2023. doi: 10.4254/wjh.v15.i4.577
Clinicopathological features of 11 cases of chronic hepatitis B infection complicated with primary biliary cholangitis
Yun Ye, Qian Zhang, Zhong-Hua Lu, You-Wen Tan
Yun Ye, Qian Zhang, You-Wen Tan, Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University, Zhenjiang 212003, Jiangsu Province, China
Zhong-Hua Lu, Department of Liver Disease, Wuxi No. 5 People’s Hospital Affiliated to Jiangnan University, Wuxi 214000, Jiangsu Province, China
Author contributions: Ye Y, Zhang Q, and Lu ZH contributed equally to the research; Tan YW and Ye Y designed the research; Zhang Q and Lu ZH collected and analyzed the data and drafted the manuscript; Tan YW performed the liver pathological evaluations; Tan YW and Ye Y wrote and revised the manuscript; all authors read and approved the final version for publication.
Supported by the Social Development Project of Jiangsu Province, No. BE2020775; and Chinese Federation of Public Health Foundation, No. GWLM202002.
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of the Third Hospital of Zhenjiang Affiliated Jiangsu University (No. 202238).
Informed consent statement: Informed consent for liver biopsy and treatments were obtained from the patients.
Conflict-of-interest statement: The authors have no conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: You-Wen Tan, MD, Chief Doctor, Professor, Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University, No. 300 Daijiamen, Runzhou Distinct, Zhenjiang 212003, Jiangsu Province, China. tyw915@sina.com
Received: January 24, 2023
Peer-review started: January 24, 2023
First decision: March 6, 2023
Revised: March 9, 2023
Accepted: March 29, 2023
Article in press: March 29, 2023
Published online: April 27, 2023
Core Tip

Core Tip: We retrospectively observed the clinicopathological features and outcomes of 11 patients with chronic hepatitis B (CHB) infection complicated by primary biliary cholangitis (PBC). We found that CHB complicated with PBC had pathological characteristics overlapping with PBC-autoimmune hepatitis. When necroinflammation of the portal area is not obvious, the pathological features of PBC are superior, similar to the features of PBC alone, this pathology is characterized by a small amount of plasma cell infiltration. Unlike PBC alone, lobulitis is often present. All patients improved after antiviral and ursodeoxycholic acid treatment and stabilized after 1 year.