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©The Author(s) 2022.
World J Hepatol. Apr 27, 2022; 14(4): 791-801
Published online Apr 27, 2022. doi: 10.4254/wjh.v14.i4.791
Published online Apr 27, 2022. doi: 10.4254/wjh.v14.i4.791
Table 1 Demographic characteristics of the study participants with and without nonalcoholic fatty liver disease
Parameters | Total, n = 183 | Non-NAFLD, n = 151 | NAFLD, n = 32 | P value |
Sex (male) | 129 (70.5%) | 103 (68.2%) | 26 (81.3%) | 0.14 |
Age (yr) | 45.41 ± 11.59 | 46.29 ± 12.01 | 41.25 ± 8.30 | < 0.01 |
BMI (kg/m2) | 23.14 ± 2.63 | 22.73 ± 2.40 | 25.05 ± 2.82 | < 0.01 |
AST (U/L) | 25 (21-32) | 25 (21-31) | 25.5 (19.75-34.53) | 0.75 |
ALT (U/L) | 28 (19-41) | 26 (19-38) | 39.5 (27-59.5) | < 0.01 |
γ-GT (U/L) | 25 (19-37) | 24 (18-32) | 39 (25-55.5) | < 0.01 |
PLT (× 109/L) | 208.37 ± 61.13 | 203.76 ± 63.49 | 230.09 ± 42.90 | 0.03 |
HBsAg (IU/mL) | 0.09 | |||
≤ 1500 | 105 (57.4%) | 91 (60.3%) | 14 (43.8%) | |
> 1500 | 78 (42.6%) | 60 (39.7%) | 18 (56.3%) | |
CRE (μmol/L) | 77.73 ± 17.96 | 77.14 ± 18.09 | 80.49 ± 17.28 | 0.34 |
UA (μmol/L) | 345.20 ± 92.53 | 332.61 ± 85.18 | 404.56 ± 103.65 | < 0.01 |
TG (μmol/L) | 1.22 ± 0.63 | 1.08 ± 0.42 | 1.85 ± 0.99 | < 0.01 |
TC (μmol/L) | 4.59 ± 0.98 | 4.52 ± 0.99 | 4.89 ± 0.82 | 0.05 |
HDL-C (μmol/l) | 1.18 ± 0.25 | 1.19 ± 0.26 | 1.11 ± 0.14 | 0.08 |
LDL-C (μmol/L) | 2.72 ± 0.68 | 2.66 ± 0.65 | 2.98 ± 0.73 | 0.02 |
ApoA1 (g/L) | 1.36 ± 0.19 | 1.36 ± 0.19 | 1.35 ± 0.15 | 0.85 |
ApoB (g/L) | 0.91 ± 0.18 | 0.89 ± 0.17 | 0.97 ± 0.18 | 0.02 |
TC/HDL-C | 3.94 ± 0.79 | 3.83 ± 0.75 | 4.44 ± 0.77 | < 0.01 |
HBV-DNA (+) | 131 (71.6%) | 116 (76.8%) | 15 (46.9%) | < 0.01 |
HBeAg (+) | 49 (26.8%) | 39 (25.8%) | 10 (31.3%) | 0.52 |
NAs | 168 (91.8%) | 144 (95.4%) | 24 (75%) | < 0.01 |
Table 2 Binary logistic regression of independent risk factors of nonalcoholic fatty liver disease
Parameters | Statistics | OR | (95%CI) | P value |
Gender (male) | 129 (70.5%) | 2.02 | (0.78-5.23) | 0.15 |
Age | 45.41 ± 11.59 | 0.96 | (0.92-1.00) | 0.03 |
BMI | 23.14 ± 2.63 | 1.40 | (1.20-1.63) | < 0.01 |
AST | 25 (21–32) | 0.99 | (0.98-1.02) | 0.99 |
ALT | 28 (19–41) | 1.01 | (1.00-1.02) | 0.04 |
γ-GT | 25 (19–37) | 1.02 | (1.01-1.04) | < 0.01 |
PLT | 208.37 ± 61.13 | 1.01 | (1.00-1.01) | 0.03 |
HBsAg (IU/mL) | 0.09 | |||
≤ 1500 | 105 (57.4%) | 0.51 | (0.24-1.11) | |
> 1500 | 78 (42.6%) | 1.95 | (0.90-4.22) | |
CRE | 77.73 ± 17.96 | 1.01 | (0.99-1.03) | 0.34 |
UA | 345.20 ± 92.53 | 1.01 | (1.00-1.01) | < 0.01 |
TG | 1.22 ± 0.63 | 6.72 | (3.07-14.71) | < 0.01 |
TC | 4.59 ± 0.98 | 1.46 | (1.00-2.15) | 0.05 |
HDL-C | 1.18 ± 0.25 | 0.19 | (0.03-1.16) | 0.07 |
LDL-C | 2.72 ± 0.68 | 1.94 | (1.11-3.39) | 0.02 |
ApoA1 | 1.36 ± 0.19 | 0.81 | (0.10-6.44) | 0.84 |
ApoB | 0.91 ± 0.18 | 11.86 | (1.37-102.86) | 0.03 |
TC/HDL-C | 3.94 ± 0.79 | 2.55 | (1.55-4.19) | < 0.01 |
HBV-DNA (+) | 131 (71.6%) | 3.74 | (1.70-8.28) | < 0.01 |
HBeAg (+) | 49 (26.8%) | 1.31 | (0.57-2.00) | 0.53 |
NAs | 168 (91.8%) | 0.15 | (0.05-0.44) | < 0.01 |
Table 3 Correlation between cholesterol to high-density lipoprotein cholesterol and nonalcoholic fatty liver disease in different models
Variable | Model 1 | Model 2 | Model 3 | ||||||
OR | 95%CI | P value | OR | 95%CI | P value | OR | 95%CI | P value | |
TC/HDL-C | 0.94 | 1.55-4.19) | < 0.01 | 0.96 | (1.52-4.51) | < 0.01 | -2.27 | (0.01-79.91) | 0.5 |
TC/HDL-C | |||||||||
≤ 3.5 | Reference | Reference | Reference | ||||||
3.5-5 | -2.53 | (0.01-0.48) | 0.01 | 1.59 | (1.10-21.94) | 0.04 | -0.64 | (0.04-6.77) | 0.63 |
> 5 | -0.77 | (0.14-1.50) | 0.2 | 2.29 | (1.60-61.40) | 0.01 | -1.74 | (0.01-14.45) | 0.44 |
P for trend | 0.02 | 0.05 | 0.73 |
Table 4 The independent correlation between cholesterol to high-density lipoprotein cholesterol and nonalcoholic fatty liver disease by multivariate piecewise linear regression
TC/HDL-C | β | 95%CI | P value |
< 4.9 | 5.4 | (2.3-12.6) | < 0.01 |
≥ 4.9 | 0.5 | (0.1-2.2) | 0.39 |
- Citation: Zhou YG, Tian N, Xie WN. Total cholesterol to high-density lipoprotein ratio and nonalcoholic fatty liver disease in a population with chronic hepatitis B. World J Hepatol 2022; 14(4): 791-801
- URL: https://www.wjgnet.com/1948-5182/full/v14/i4/791.htm
- DOI: https://dx.doi.org/10.4254/wjh.v14.i4.791