Zhou YG, Tian N, Xie WN. Total cholesterol to high-density lipoprotein ratio and nonalcoholic fatty liver disease in a population with chronic hepatitis B. World J Hepatol 2022; 14(4): 791-801 [PMID: 35646261 DOI: 10.4254/wjh.v14.i4.791]
Corresponding Author of This Article
Wei-Ning Xie, MD, Professor, Department of Scientific Research, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, No. 16 Guicheng South Fifth Road, Nanhai District, Foshan 528200, Guangdong Province, China. xwn1219@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Apr 27, 2022; 14(4): 791-801 Published online Apr 27, 2022. doi: 10.4254/wjh.v14.i4.791
Total cholesterol to high-density lipoprotein ratio and nonalcoholic fatty liver disease in a population with chronic hepatitis B
Yu-Ge Zhou, Ning Tian, Wei-Ning Xie
Yu-Ge Zhou, Affiliated Guangdong Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Foshan 528200, Guangdong Province, China
Ning Tian, Preventive Healthcare Center, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Foshan 528200, Guangdong Province, China
Wei-Ning Xie, Department of Scientific Research, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Foshan 528200, Guangdong Province, China
Author contributions: Xie WN designed the study, constructed the research ideas and interpreted the data; Zhou YG participated in the acquisition and analysis of the data and drafted the initial manuscript; Tian N supervised the project process and revised the article critically for important intellectual content.
Institutional review board statement: This research project was submitted to and approved by the Ethics Committee of Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine (Approval number: 2018-1254).
Informed consent statement: No informed consent was required because this was a retrospective observational study.
Conflict-of-interest statement: There were no conflicts of interest to report.
Data sharing statement: No additional data was available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Ning Xie, MD, Professor, Department of Scientific Research, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, No. 16 Guicheng South Fifth Road, Nanhai District, Foshan 528200, Guangdong Province, China. xwn1219@qq.com
Received: October 20, 2021 Peer-review started: October 20, 2021 First decision: November 17, 2021 Revised: December 13, 2021 Accepted: April 3, 2022 Article in press: April 3, 2022 Published online: April 27, 2022 Processing time: 184 Days and 0.9 Hours
ARTICLE HIGHLIGHTS
Research background
Due to the growing prevalence of nonalcoholic fatty liver disease (NAFLD), the coexistence of hepatitis B virus (HBV) infection and NAFLD is commonly observed around the world. However, the cross-talk between these two diseases remained questionable.
Research motivation
Previous studies showed that the total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C) was a better predictor of NAFLD than other lipid metabolism biomarkers and might be a new indicator of NAFLD. However, the association between TC/HDL-C and NAFLD in an HBV-infected population has not been previously investigated.
Research objectives
To investigate the association between TC/HDL-C and NAFLD in a CHB population.
Research methods
Univariate and multivariate logistic regression models, curve fitting analysis and threshold calculations were used to assess the relationship between TC/HDL-C and NAFLD.
Research results
A non-linear association was detected between TC/HDL-C and NAFLD in the CHB population at an inflection point of 4.9. The effect size on the left and right sides of inflection point were 5.4 (95%CI: 2.3-12.6, P < 0.01) and 0.5 (95%CI: 0.1-2.2, P = 0.39), respectively.
Research conclusions
In the CHB population, the relationship between TC/HDL-C and NAFLD was non-linear. TC/HDL-C was positively correlated with NAFLD when TC/HDL-C was less than 4.9.
Research perspectives
Further large-scale cohort studies are needed to validate whether TC/HDL-C is indeed a better predictor of NAFLD than other lipid metabolism biomarkers in the CHB population.
