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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Apr 27, 2022; 14(4): 791-801
Published online Apr 27, 2022. doi: 10.4254/wjh.v14.i4.791
Published online Apr 27, 2022. doi: 10.4254/wjh.v14.i4.791
Total cholesterol to high-density lipoprotein ratio and nonalcoholic fatty liver disease in a population with chronic hepatitis B
Yu-Ge Zhou, Affiliated Guangdong Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou University of Chinese Medicine, Foshan 528200, Guangdong Province, China
Ning Tian, Preventive Healthcare Center, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Foshan 528200, Guangdong Province, China
Wei-Ning Xie, Department of Scientific Research, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Foshan 528200, Guangdong Province, China
Author contributions: Xie WN designed the study, constructed the research ideas and interpreted the data; Zhou YG participated in the acquisition and analysis of the data and drafted the initial manuscript; Tian N supervised the project process and revised the article critically for important intellectual content.
Institutional review board statement: This research project was submitted to and approved by the Ethics Committee of Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine (Approval number: 2018-1254).
Informed consent statement: No informed consent was required because this was a retrospective observational study.
Conflict-of-interest statement: There were no conflicts of interest to report.
Data sharing statement: No additional data was available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Ning Xie, MD, Professor, Department of Scientific Research, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine, No. 16 Guicheng South Fifth Road, Nanhai District, Foshan 528200, Guangdong Province, China. xwn1219@qq.com
Received: October 20, 2021
Peer-review started: October 20, 2021
First decision: November 17, 2021
Revised: December 13, 2021
Accepted: April 3, 2022
Article in press: April 3, 2022
Published online: April 27, 2022
Processing time: 184 Days and 0.9 Hours
Peer-review started: October 20, 2021
First decision: November 17, 2021
Revised: December 13, 2021
Accepted: April 3, 2022
Article in press: April 3, 2022
Published online: April 27, 2022
Processing time: 184 Days and 0.9 Hours
Core Tip
Core Tip: Nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis B (CHB) are both common chronic liver diseases. In this observational cross-sectional study, we explored the association between NAFLD and a lipid metabolism biomarker [the total cholesterol to high-density lipoprotein cholesterol ratio, total cholesterol to high-density lipoprotein cholesterol ratio (TC/HDL-C)] in a population with CHB. Our findings showed a non-linear correlation between TC/HDL-C and NAFLD. TC/HDL-C was positively associated with NAFLD when TC/HDL-C was less than 4.9 but not when TC/HDL-C was more than 4.9.