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Copyright ©The Author(s) 2021.
World J Hepatol. Oct 27, 2021; 13(10): 1367-1377
Published online Oct 27, 2021. doi: 10.4254/wjh.v13.i10.1367
Table 1 Mechanisms of coronavirus disease 2019 liver injury
Mechanisms
Pathophysiology
Direct cytotoxicityActive replication of SARS-CoV-2 in hepatic cells
Hyper-inflammatory reactionCytokine storm and activation of immune system
Systemic hypoxiaCOVID-19 cardiomyopathy
Drug-induced liver injuryLiver toxicity to medication used to treat COVID-19
Table 2 Influence of liver diseases in risk of infection or outcome of coronavirus disease 2019
Higher risk of infection or severe outcome of COVID-19
Apparently non-higher risk of infection or severe outcome of COVID-19
Non-alcoholic fatty liver diseaseHemochromatosis
Alcoholic liver diseaseWilson's disease
Alpha-1 antitrypsin deficiencyAutoimmune liver disease
CirrhosisHepatitis B infection
Hepatocellular carcinoma