Published online Oct 27, 2021. doi: 10.4254/wjh.v13.i10.1367
Peer-review started: May 28, 2021
First decision: June 27, 2021
Revised: July 11, 2021
Accepted: August 31, 2021
Article in press: August 31, 2021
Published online: October 27, 2021
The global pandemic of coronavirus disease 2019 (COVID-19) changed dramatically all priorities on medical society and created several challenges for clinicians caring for patients with liver diseases. We performed a comprehensive review about how COVID-19 can affect the liver, the influence of liver diseases on the risk of developing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 severity and also some strategies to overcome all the challenges clinicians have to face in the management of patients with liver diseases in a period of time when all the focus turned on COVID-19. We analyze the relationship between COVID-19 and non-alcoholic fatty liver disease, alcoholic liver disease, viral hepatitis, autoimmune liver disease, cirrhosis, hepatocellular carcinoma and liver transplantation, as well as the approach to SARS-CoV-2 vaccination.
Core Tip: Coronavirus disease 2019 (COVID-19) has become a major health problem worldwide in the last few months, affecting the health system dramatically. Apart from the respiratory system, associated liver injury is one of the main concerns in severe acute respiratory syndrome coronavirus 2 infection and several mechanisms could explain liver abnormalities. In this mini-review, and different from other papers, we not only analyze liver injury by COVID-19, the effect of COVID-19 in liver diseases, its pathophysiology and strategies to keep an adequate care of liver patients, but also highlight the potential higher risk of severe disease or risk of infection in patients with different etiologies of liver disease. We also analyze the recent recommendations and prioritization regarding vaccination in patients with liver disease.